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Place of publication: psychopharmacology and biological narcology / t. 15, No. 1, 2024

Ryazan State Medical University named after Acad. I.P. Pavlova, Ryazan, Russia

Annotation
relevance. A disorder caused by the use of alcohol (ethanol) is a destructive state in which there is a violation of energy and metabolic processes, as well as the activation of processes of free radical oxidation. That is why the use of antioxidants, in particular the original domestic drug ethylmethydlhydroxypyridine of succinate, is pathogenetically substantiated in the complex therapy of this pathology.
The goal is to study the effectiveness of ethylmethylhydroxypyridine of succinate in intravenous, intramuscular and intravenous methods of introducing ICR mice in modeling alcohol withdrawal.
Materials and methods. The study was performed on healthy, free from the pathogenic flora of mice, outbuilding ICR runoff at the age of 9-10 weeks. In an average mass of 25.4 ± 0.2 g. Alcoholic dependence in animals was modeled with a gradual increase in ethanol in a drinker from 1 to 3, 6, 10 % every 2 days. Upon reaching
a concentration of 10 %, animals were given 1 bottle of alcohol with 1 bottle of water every other day and 2 bottles of alcohol on intermediate days. The position of the bottles (left / right) changed between each access session to alcohol. After 6 weeks of animals, a solution of 10 % alcohol was removed. The introduction of ethylmethylhydroxypyridine of succinate and saline
(control group) 2 times a day for 7 days began. The drug was administered intravenously (50 and 100 mg/kg), intramuscularly (50 and 100 mg/kg) and intravenous (100 and 150 mg/kg).
Results. This study establishes that ethyl methylhydroxypyridine is succinate (Mexidol® with intravenous (50 and 100 mg/kg), intramuscular (50 and 100 mg/kg) and intravenous (100 and 150 mg/kg) administration 2 times a day for 7 days with manifestations of alcohol dependence in alcohol dependence in the mice of
the ICR, possesses a pronounced Pharmacological activity, which is manifested in a decrease in the volume of alcohol consumption, improved horizontal and vertical activity in the “open field” test, improving the coordination of movements, reducing the severity of the withdrawal syndrome revealed in the test to the
nesting . MG/kg), intramuscular (50 and 100 mg/kg) and intravenous (100 and 150 mg/kg) introduction of ICR for mice, have a pronounced therapeutic effect in the modeling of alcohol withdrawal:
ethylmethylhydroxypydine sequisinate; Healthy SPF mice ICR.

How to quote
Yakusheva E.N., Schulkin A.V., Abalenikhina Yu.V. Assessment of the effectiveness of ethylmethylhydroxypyridine of succinate with alcohol withdrawal //
Psychopharmacology
and biological narcology. 2024. T. 15, No. 1. S. 61–68. Doi: https://doi.org/10.17816/phbn625395

Place of publication:
a journal of neurology and psychiatry named after S.S. Korsakova, 2021, T. 121, No. 6

Summary:
the state of cancellation of alcohol develops with the refusal of drinking alcohol, after prolonged or short -lived, but their massive use, is manifested by somatic symptoms and, in some cases, is complicated by the development of alcoholic seizures, alcoholic hallucinosis and alcohol delirium, which can create a threat to patients. The leading neurochemical factors underlying alcohol cancellation and its complications are the insufficient cerebral content of the GABA and the excessive activity of glutamate, which matters to therapy. First -line preparations in the treatment of alcohol and alcoholic delirium cancellation are benzodiazepines with maximum pharmacological similarities with ethanol. As an alternative to benzodiazepines and in addition to them, especially in the case of protracted delirium with therapeutic resistance, other drugs, including barbiturates, antiepileptic drugs, propofols, dexemedetomidine and antipsychoticism, can be used. Certain prospects in the treatment of alcohol cancellation syndrome are associated with ethylmethylhydroxypyridine with a succinate, which has some pharmacological similarity with benzodiazepines. Key words: alcohol disorders, alcohol cancellation syndrome, alcohol convulsions, alcoholic hallucinosis, alcoholic delirium, benzodiazepines.

Place of publication:
a journal of neurology and psychiatry named after S.S. Korsakova, 2020, T. 120, No. 5

Summary:
A review of modern literature is presented regarding the use of Mexidol (ethylmethylhydroxypyridine succinate) in the treatment of mental (in particular, addictive) disorders. The possibility of its prescription for the correction of negative psychopathological symptoms, neurocognitive deficiency, manifestations of neuroleptic syndrome (including its extrapyramidal disorders) in the treatment of antipsychotics in patients with schizophrenic spectrum, insomnic disorders in the complex therapy of border mental disorders is shown. The possibilities of the use of the drug Mexidol in the treatment of addictive pathology, as well as the consequences of intoxication caused by alcohol and other psychoactive (in particular, narcotic) substances deserve. Key words: mental disorders, addictive pathology, Mexidol, treatment, complex therapy.

The purpose of the study . Assessment of the dynamics of the functional activity of the structures of the brain that provide cognitive functions in patients with encephalopathy in acute poisoning with neurotoxic substances at the rehabilitation stage.

Material and methods. 56 patients were examined. The main group was 40 patients, for the treatment of which the intravenous drip administration of Mexidol was used - 10 patients, a combination of Mexidol with non -drug methods of treatment in the form of mesodyeencephalic modulation (MDM) - 10 patients, hyperbaric oxygenation (HBO) - 10 patients and combinations of MDM and HBO - 10 patients. The comparison group was 16 people. All patients were recorded by EEGs caused by auditory (associated event) potentials (SSP) and carried out neuropsychological testing. Results and conclusion. EEG changes noted in all their severity examined with their great severity, and the dominance of signs of violation of the functional activity of the formations of
the diencephalic or mesodyeencephalous level was noted. After the treatment in the main group, positive dynamics was detected in 60% of cases. In 80% of cases, positive dynamics was noted when using a combination of Mexidol, MDM and HBO. Negative dynamics in the main group was noted in 5 (12.5%) cases, while it was more often detected when only Mexidol was used in the treatment process. The results of the primary neuropsychological study showed that in the main group in 97.5% of cases and in 100% of patients of the comparison group, violations of cognitive activity of varying degrees of severity were detected. After the treatment in patients of the main group, 62.5% improved indicators for neuropsychological tests, there was a reduction in the latent period of components N200, P300, an increase in the amplitude of the caused potentials. Thus, the use of patients with encephalopathy in acute poisoning with various neurotoxicants at the stage of rehabilitation of Mexidol, HBO and MDM leads to an improvement in the indicators that reflect the functional state of the brain as a whole and the state of cognitive functions.

Keywords: encephalopathy, acute neurotoxicant poisoning, electroencephalography, auditory -related potential (P300), psychophysiological testing, mexidol, mesodyeencephalmic modulation, hyperbaric oxygenation.

Place of publication:
Journal of Neurology and Psychiatry, 2, 2013

Summary:
70 patients with panic disorder (PR), 30 men and 40 women were examined, whose average age was 34.5 ± 1.8 years. All patients were distinguished by the presence of dissocation disorders. Patients, depending on the characteristics of therapy, were divided into 2 groups - control and basic. Patients of the control group were treated only with an antidepressant (freedin at a dose of 150 mg per day); Mexidol (375 mg per day) was appointed to patients of the main group to antidepressant.

Place of publication:
Bulletin of experimental biology and medicine, 2012, Appendix 1

Summary:
In the treatment of patients with opium drug addiction by Mexidol and convulsan, the symptoms of withdrawal and postbustified disorders were reduced faster and to a greater extent than in the treatment according to the standard methodology. Patients used to become capable of socio-non-norment behavior, to constructive and productive actions in the treatment and rehabilitation process. Key words: Mexidol, convulsan, lamotridine, drug addiction, withdrawal disorders.

Place of publication:
Bulletin of experimental biology and medicine, 2006, Appendix 1

Summary:
Mexidol is an effective, economical treatment for a comprehensive treatment of convulsive syndrome of withdrawal genesis, prevents recurrence of convulsive attacks, significantly improves overall well -being and cognitive functions for a shorter period of time than other nootropic drugs. Key words: withdrawal, injury, convulsive syndrome, cognitive functions, Mexidol.

Place of publication:
Journal of Neurology and Psychiatry, 11, 2006

Summary:
the results of the clinical assessment of the effectiveness and tolerance of Mexidol are presented with its intravenous drip administration within 5-7 days in 50 cases of complicated alcohol delirium by Mexidol. The clinical condition of the patients and the dynamics of laboratory data were evaluated in comparison with the control group of patients on basic therapy without Mexidol. It was established that the use of Mexidol allows you to stop psychosis as early as possible, which in turn leads to a decrease in secondary complications and mortality. Key words: Mexidol, antioxidant, antihypoxant, alcoholic delirium, stopping.

Place of publication:
Bulletin of experimental biology and medicine, 2006, Appendix 1

Summary:
Mexidol was used in the treatment of various options for alcohol withdrawal syndrome. Thanks to the expressed vegetostabilizing and sedative effects of Mexidol’s therapy, it was more effective than complex traditional therapy in the removal of neurovegetative and psychopathological manifestations. Key words: alcoholism, withdrawal syndrome, Mexidol.

Place of publication:
Bulletin of experimental biology and medicine, 2006, Appendix 1

Summary:
the clinical effectiveness and validity of the use of Mexidol in the complex therapy of patients with post -traumatic stress disorders with typical psychopathological symptoms has been studied. The dynamics of changes in not only quantitative (experimental-psychological) indicators, but also of qualitative (clinical) features were taken into account. With the use of Mexidol, emotional lability decreased in 6% of cases, the intensity of headaches - in 36%, the level of alcoholization - in 37%, the mood background increased in 59% of cases, the level of asthenization was normalized in 82.6% of cases, the level of anxiety decreased to the norm In 70% of cases. Normalizing the processes in the central nervous system, increasing the adaptive reserves of the body, Mexol, enhances effectiveness and reduces side effects of the use of antidepressants and benzodiazepines. Thus, Mexidol is a promising drug in the treatment of post -traumatic stress disorders. Key words: post -traumatic stress disorder, Mexidol, adaptive reserves, social fences, anxiolytic activity.

Place of publication:
Bulletin of experimental biology and medicine, 2006, Appendix 1

Summary:
30 patients with neurotic conditions and the predominance of depressive, anxious, hysterical symptoms were examined. The effect of Mexidol was evaluated on the level of depression, anxiety, memory and attention. The positive effect of the drug is noted that contributes to social adaptation and improve the quality of life of patients. Key words: neurosis, depression, therapy, neurometabolic products, Mexidol.