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The purpose of the study is to study the effectiveness and safety of the early use of Mexidol in the acute period of severe ischemic stroke (AI). Material and methods. The study included 112 patients aged 35–85 years with severe AI. Patients were divided into two groups comparable by gender and age. The main group (n = 59) received Mexidol at a dose of 400 mg per day intravenously for 10 days and basic therapy. The comparison group (n = 53) received only basic therapy. Results and discussion. In the main group, the share of favorable outcomes in severe AI in both early and delayed treatment (on the Rankin scale) was higher than in the comparison group, and mortality is significantly lower. The results of the study showed that the use of Mexidol increases the effectiveness of therapy. The drug can be recommended for the treatment of patients with severe carotid AI.

Key words: heavy ischemic stroke, Mexidol, treatment.

Place of publication:
Medical alphabet No. 19/2017, volume No. 3. Emergency medicine

Summary:
relevance. Neuroprotection is a mandatory component of intensive care of cerebral disasters in the prehospital and hospital stages of medical care. Target. Identification of the characteristics and adequacy of the ambulance personnel of the methods of neuroprotheres in various cerebral disasters. Materials and methods. To determine the level of knowledge and practical skills of neuroprotection of various cerebral disasters, anonymous voluntary questioning of 109 doctors of the SMP stations and 103 paramedics of the Voronezh city ambulance station was carried out. The effectiveness of the use of neuroprotectors for cerebral disasters was studied using a special protocol attached to the Chargage map of the Voronezh ambulance station. Results. Theoretical training in the neuroprotection section is considered sufficient 75 % of doctors and 57 % of paramedics. 25 % of doctors and 35 % of paramedics are considered insufficient theoretical training. The use of Mexidol intensive therapy in the intensive care of the prehospital stage has a pronounced positive clinical effect.