Mexidol in the complex therapy of post -traumatic stress disorders

Authors:
S.A. TsAREGORODTSEVA, M.YU. BONDARENKO, VAKHRANEVA E.V., AZIN A.L.

Republican Clinical Hospital for War Veterans;
Center for Medical, Psychological, and Social Rehabilitation of Veterans of Combat and Counter-Terrorism Operations and Their Families, Yoshkar-Ola

Place of publication:
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2006, APPENDIX 1

Abstract:
The clinical efficacy and feasibility of Mexidol in the combination therapy of patients with post-traumatic stress disorder (PTSD) and typical psychopathological symptoms were studied. The dynamics of changes in both quantitative (experimental psychological) and qualitative (clinical) parameters were considered. With Mexidol use, emotional lability decreased in 6% of cases, headache intensity decreased in 36%, alcoholization decreased in 37%, mood improved in 59%, asthenia returned to normal in 82.6%, and anxiety decreased to normal in 70% of cases. By normalizing processes in the central nervous system and increasing the body's adaptive reserves, Mexidol enhances the effectiveness and reduces the side effects of antidepressants and benzodiazepines. Thus, Mexidol is a promising drug for the treatment of post-traumatic stress disorder (PTSD). Key words: post-traumatic stress disorder, mexidol, adaptation reserves, social withdrawal, anxiolytic activity.