Library

Place of publication:
a journal of neurology and psychiatry named after S.S. Korsakova, No. 4, 2019

Summary:
the review presents data on the combined use of Mexidol in combination with drugs of various pharmacotherapeutic groups. Possessing the multimodal action mechanism and a wide range of pharmacological effects, Mexoling enhances the main effect of drugs both in the experiment and in the clinic, increases the effectiveness of therapy prescribed by patients in accordance with current federal standards, and also helps to reduce the severity of complications of diseases. The data on the efficiency and pathogenetic validity of the course combination therapy with other preparations presented in the review indicate the advisability of this approach for the treatment of cerebrovascular and cardiovascular diseases, diseases of the nervous system, open-angle glaucoma, alcohol intoxication and a number of other diseases. Key words: Mexidol, combined therapy, free radicals, lipid oxidation, ischemic stroke, myocardial infarction, coronary heart disease, epilepsy, glaucoma, alcohol intoxication.

Place of publication:
a journal of neurology and psychiatry, No. 12, 2012

Summary:
Mexidol (2-El-methyl-3-gydro Xipina Ridina Succinate)-a domestic original antioxidant and anti-hyphyxant, created at the Research Institute of Pharmacology of the RAMS in the mid-80s. Mexol consists of two related and functionally significant compounds: 2-ethyl-6-methyl-3-hydroxypyridine and amber acid. The presence of 3-hydroxypyridine in the structure of Mexidol provides a complex of its antioxidant and membranotropic effects, the ability to reduce glutamate excanitotoxicity, modulate the functioning of receptors, which fundamentally distinguishes Mexol from other preparations containing amber acid. The presence of succinate in the structure of Mexidol distinguishes it from Emoxypin and other 3-oxypyridine derivatives, since the succinate is functionally significant for many processes occurring in the body and, in particular, is a substrate for increasing energy metabolism in the cell.

Place of publication:
Pharmacate, No. 6, 2009

Summary:
The article presents viewing data on pharmacological effects and pharmacokinetics of Mexidol. Neuroprotective, anti -hypic, anti -ischemic, nootropic, anti -stress, anxiolytic, anticonvulusal, anti -alcohol, anti -anatherogenic, heroesidal action of Mexidol is considered. Particular attention is paid to the effects of Mexidol in the treatment of diseases occurring with neurodegeneration, primarily acute and chronic disorders of cerebral circulation. Information is presented about the polycomponent mechanism of action of Mexidol, the important links of which are its antioxidant, membrane effects, the ability to modulate the functioning of receptors and membrane -raised enzymes, as well as restore the neurotransmitted balance.

Year of publication: 2004

Summary:
in recent years, close attention of pharmacologists and clinicians as promising drugs that effectively regulate oxidation and peroxidation processes attracted compounds of heteroamatic phenols, in particular, 3-oxypyrin derivatives. 3-oxypyridine derivatives (3-OP) belong to the simplest heterocyclic analogues of aromatic phenols and in this regard show antioxidant and anti-radical properties. They are structural analogues of the compounds of the Vitamin B6 group (pyridoxol, pyridoxal and pyridoxamine), playing an important role in the life of the body. The synthesis and analysis of the physicochemical properties of a number of original derivatives of 3-Op was carried out by L.D. Smirnov, K.M. Dyumaev, V.I. Kuzmin, and their pharmacological study was carried out in the laboratory of psychopharmacology of the Research Institute of Pharmacology of the Russian Academy of Sciences under the guidance of a honored science figure of Professor T.A. Voronina.