Preclinical experimental studies

Registered on ClinicalTrials

Results of an international multicenter, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of sequential therapy with ethylmethylhydroxypyridine succinate in patients in the acute and early recovery periods of ischemic stroke (IS)

The results of a cohort -center randomized study of the modulating effect of Mexidol® in the rehabilitation of patients who have undergone acute cerebral failure

The value of mitochondrial dysfunction in stabilization

The results of a multicenter dual blind randomized placebo-controlled clinical study on the assessment of the effectiveness and safety of the drug Mexidol in the treatment of attention deficit syndrome in children (mega)

The results of an international multicenter randomized double-blind-controlled study of evaluating the effectiveness of the effectiveness and safety of consistent therapy of patients with chronic brain ischemia with Mexidol and Mexidol Forte 250 (study of Memo)

The results of a randomized double blind multicenter placebo-controlled in parallel groups of the study and safety of Mexidol with prolonged consistent therapy in patients in the acute and early recovery periods

The results of a cohort -center randomized study of the modulating effect of Mexidol® in the rehabilitation of patients who have undergone acute cerebral failure

The value of mitochondrial dysfunction in stabilization

Study of drug interactions between Mexidol and thrombolytic drugs

A.V. SHCHULKIN, I.V. CHERNYKH, Yu.V. ABALENIKHINA, M.V. GATSANOGA, M.M. GRADINAR,
P.D. ANANYEVA, E.N. YAKUSHEVA

FGBOU in the Ryazan State Medical University named after Acad. I.P. Pavlova "of the Ministry of Health of Russia, Ryazan, Russia

Place of publication:
S.S. Korsakov Journal of Neurology and Psychiatry 2025, Vol. 125, No. 9, pp. 139–144
https://doi.org/10.17116/jnevro2025125091139

The effect of Mexidol on the level of neurogenesis markers in acute cerebrovascular disorders in the experiment

Authors:

A.V. Schulkin, I.V. Chernykh, Yu.V. Abalenikhina, M.V. Gatsanoga, O.A. Andryushin, N.A. Kruzhalov, E.N. Yakusheva

FGBOU in the Ryazan State Medical University named after Academician I.P. Pavlova "of the Ministry of Health of Russia, Ryazan, Russia

Place of publication:

S.S. Korsakov Journal of Neurology and Psychiatry
2025, Vol. 125, No. 2, pp. 107–112

The study of the influence of ethylmethylhydroxypyridine of succinate on the effectiveness of non -steroidal anti -inflammatory drugs with visceral and somatic pain in the experiment on mice and rats

Author:
IVANOVA E.A., VASILCHUK A.G., MATYUSHKIN A.I. , VORONINA T.A.

FGBNU "Research Institute of Pharmacology named after V.V. Zakusova ”, Moscow, Russia

The role of oxidative stress in acute experimental hemorrhagic stroke and therapeutic effects of Mexidol

Authors:
VORONINA T.A., KRAYNEVA V.A., ZOLOTOV N.N., KOTELNIKOVA S.O., VALDMAN E.A.

FGBNU "Research Institute of Pharmacology named after V.V. Zakusova ”, Moscow, Russia

The influence of Mexidol on cerebral mitochondriogenesis at a young age and with aging

Authors:
KIROVA Yu.I. 1*, SHAKOVA F.M. 1*, GERMANOVA E.L. 1*, ROMANOVA G.A. 1*, VORONINA T.A. 2*

1* Federal State Budgetary Scientific Institution "Research Institute of General Pathology and Pathophysiology", Moscow, Russia;
2* Federal State Budgetary Scientific Institution "V.V. Zakusov Research Institute of Pharmacology", Moscow, Russia

Heroprotective effects of ethylmethylhydroxypyridine of succinate in an experimental study

Author:
VORONINA T.A.

FGBNU "Research Institute of Pharmacology named after V.V. Zakusova ”, Moscow, Russia

The effect of Mexidol on physical performance and lactate in the blood of rats in conditions of light desingronosis

Authors

GOSTYUKHINA A.A., ZAITSEV K.V.ZAMOSCHINA T.A., Svetlik M.V.

Place of publication:

Journal of Neurology and Psychiatry, 11, 2018

The influence of Mexidol on the expression of the NRF2 transcription factor in the cortex of the large hemispheres of the brain with experimental ischemia

Authors:
YAKUSHEVA E.N., MYLNIKOV P.Yu., CHERNYKH I.V., SHCHULKIN A.V.

FGBOU in the Ryazan State Medical University named after Acad. I.P. Pavlova "of the Ministry of Health of Russia, Ryazan, Russia

Place of publication:
JOURNAL OF NEUROLOGY AND PSYCHIATRY, 5, 2018

The influence of Mexidol on the expression of the factor induced by HIF-1α hypoxia in the cortex of the large hemispheres of the brain of rats with ischemia

Authors:
YAKUSHEVA E.N., MYLNIKOV P.Yu., CHERNYKH I.V., SHCHULKIN A.V.

FGBOU in the Ryazan State Medical University named after Acad. I.P. Pavlova ", Ryazan, Russia

Geronto -informational analysis of the properties of the Mexidol molecule

Authors:
GROMOVA O.A. ^1.2*, TORSHIN I.Yu.^2*, FEDOTOVA L.E. ^1*

^1*Federal State Budgetary Educational Institution of Higher Education "Ivanovo State Medical Academy", Ivanovo;
^2*Federal Research Center "Informatics and Control" of the Russian Academy of Sciences, Moscow

Comparative chemoreactic analysis of Mexidol

Authors:
TORSHIN I.YU. ^1*, GROMOVA O.A. ^2*, SARDARYAN I.S. ^3*, FEDOTOVA L.E.^3*

^1*Moscow Institute of Physics and Technology, Dolgoprudny, Russia;
^2*Ivanovo State Medical Academy of the Ministry of Health of the Russian Federation, Ivanovo, Russia;
^3*Saint Petersburg State Pediatric University of the Ministry of Health of the Russian Federation, Saint Petersburg, Russia

The distribution of Mexidol in the structures of the brain, its cellular elements and subcellular fractions

Authors:
SHCHULKIN A.V., YAKUSHEVA E.N., CHERNYKH I.V.

Ryazan State Medical University named after Academician I.P. Pavlova

Mexidol and hepatitis: the results in the experiment and prospects in the clinic

Author:
FARASCHUK N.F.

GOU VPO Smolensk State Medical Academy

Features and mechanism of the neuroprotective action of Mexidol with hemorrhagic stroke in the experiment

Author:
V.A. KRAINEVA

GU Nii Pharmacology named after V.V. Zakusov RAMS, Moscow