Heroprotective effects of ethylmethylhydroxypyridine of succinate in an experimental study

Author:
VORONINA T.A.

FGBNU "Research Institute of Pharmacology named after V.V. Zakusova ”, Moscow, Russia

Place of publication:
S.S. KORSAKOV JOURNAL OF NEUROLOGY AND PSYCHIATRY, 2020, Vol. 120, No. 4

Abstract:
Objective. To study the effect of Mexidol on cognitive and motor functions impaired during aging, seizure threshold, body weight, and lifespan in old male Wistar rats. Material and Methods. In a long-term experiment, cognitive impairment (conditioned passive avoidance reflex test), motor impairment (rotator crank and pull-up tests), seizure threshold (subcutaneous pentylenetetrazole test), body weight, and lifespan were assessed in male Wistar rats. Rats received Mexidol as a 0.15% solution, which replaced drinking water, in two courses of 2 months each: at the ages of 18-20 and 22-24 months. The dose of Mexidol consumed by rats was 40-75 mg/kg/day. Results. In aged male Wistar rats, Mexidol, administered over a long period of time, improves learning, retention, and retrieval of a memory trace in a conditioned passive avoidance reflex test. It also increases the seizure threshold, improves muscle tone and motor coordination, which are impaired with aging, and prolongs lifespan. Mexidol prevents the significant weight gain characteristic of aging. Conclusion. Mexidol reduces the severity of cognitive and neurological deficits that occur with aging in male Wistar rats, increases the seizure threshold, and prolongs lifespan, which is determined by its ability to influence mitochondriogenesis and its antioxidant properties. Keywords: aging, Mexidol, lifespan, memory impairment, neurological deficit, seizure threshold.