The study of the influence of ethylmethylhydroxypyridine of succinate on the effectiveness of non -steroidal anti -inflammatory drugs with visceral and somatic pain in the experiment on mice and rats

Author:
IVANOVA E.A., VASILCHUK A.G., MATYUSHKIN A.I. , VORONINA T.A.

FGBNU "Research Institute of Pharmacology named after V.V. Zakusova ”, Moscow, Russia

Place of publication:
S.S. KORSAKOV JOURNAL OF NEUROLOGY AND PSYCHIATRY, 2023, Vol. 123, No. 12

Abstract:
Objective. To study the effect of ethylmethylhydroxypyridine succinate (EMHPS) on the analgesic effect of the non-selective cyclooxygenase (COX) inhibitor diclofenac sodium and the selective COX-2 inhibitor etoricoxib in models of acute visceral and somatic pain and to evaluate the possibility of using EMHPS in combination with COX inhibitors to reduce their doses while maintaining analgesic efficacy. Material and Methods. We studied the effect of EMHPS after a single oral administration on the analgesic effects of non-steroidal anti-inflammatory drugs (NSAIDs): non-selective COX inhibitor diclofenac sodium and selective COX-2 inhibitor etoricoxib in models of acute visceral (vinegar writhe test) and somatic pain (formalin test and mechanical hyperalgesia test during inflammation) in an experiment on mice and rats. Results. In a model of acute visceral pain in mice, EMHPS (25-100 mg/kg) has no significant effect on its severity, but enhances the analgesic effect of diclofenac sodium (0.5 mg/kg) and etoricoxib (1 mg/kg). In a formalin test in rats simulating pain due to surgical incisions (trauma), EMHPS (25 mg/kg) enhances the analgesic effect of COX inhibitors (1 mg/kg), primarily by reducing pain in the acute phase caused by the effect of formalin on afferent neurons. In a model of mechanical hyperalgesia in rats induced by exudative inflammation after injection of carrageenan solution into the paw, EMHPS enhances the effect of diclofenac to a greater extent than etoricoxib. Conclusion. The obtained data indicate the feasibility of a clinical trial of the use of EMHPS in combination with NSAIDs for visceral and somatic pain to assess its ability to enhance the therapeutic effect of NSAIDs. Key words: ethylmethylhydroxypyridine succinate, nonsteroidal anti-inflammatory drugs, visceral pain, somatic pain, mice, rats.