Pharmacology of antioxidants based on 3-oxypyridine

Authors:
NOVIKOV V.E., KOVALEVA L.A., LOSENKOVA S.O., KLIMKINA E.I.

Smolensk State Medical Academy

Year of publication: 2004

Abstract:
In recent years, heteroaromatic phenol compounds, particularly 3-oxypyridine derivatives, have attracted the attention of pharmacologists and clinicians as promising drugs that effectively regulate oxidation and peroxidation processes. 3-Hydroxypyridine (3-OP) derivatives are among the simplest heterocyclic analogues of aromatic phenols and therefore exhibit antioxidant and antiradical properties. They are structural analogues of compounds of the vitamin B6 group (pyridoxole, pyridoxal, and pyridoxamine), which play an important role in the body's vital functions. The synthesis and analysis of the physicochemical properties of a number of original 3-OP derivatives were carried out by L.D. Smirnov, K.M. Dyumaev, and V.I. Kuzmin, and their pharmacological study was conducted in the Psychopharmacology Laboratory of the Research Institute of Pharmacology of the Russian Academy of Medical Sciences under the supervision of Honored Scientist Professor T.A. Voronina.