Library

Place of publication:
a journal of neurology and psychiatry named after S.S. Korsakova, 2022, T. 122, No. 5

Summary:
Purpose of the study. To study the leading pathogenetic mechanisms that underlie the development of complications of diabetes (diabetes) of the 2nd type and optimize therapeutic approaches to the treatment of this category of patients. Material and methods. The results of treatment are presented 30 patients suffering from type 2 diabetes and its complications who received Mexidol in/in a drop of 500 mg/day for 14 days, with the subsequent transition to the oral reception of Mexol Fort 250 to 250 mg 3 times a day in the course of 60 days. The dynamics of the condition was evaluated by standardized neuropsychological scales. Clinical and biochemical studies are performed according to the protocol of patients with type 2 diabetes. Results. Mexidol therapy according to the presented scheme was accompanied by an improvement in cognitive functions, a decrease in signs of asthenia, anxiety and depression, normalization of sleep, improving biochemical blood indicators, and an increase in the quality of life. Conclusion. The appointment of Mexidol in the form of consistent prolonged therapy may be an effective approach, which allows you to improve the quality of life of patients with type 2 diabetes. Keywords: diabetes, hypoxia, oxidative stress, antioxidants, neurotransmitters, antihypoxants, Mexidol.

Place of publication:
New therapeutic journal Non Nocera, August 2021

Summary:
For centuries, every representative of the fair sex wanted to stay young and beautiful as long as possible. For this, for example, Queen Cleopatra or Queen of England Elizabeth I daily took baths with milk (cows, goats, donkeys, etc.). In the Victorian era, women for the sake of whiteness of skin applied creams containing lead, which definitely did not contribute to health and a long happy life, the duration of which began to increase only in the twentieth century against the backdrop of the rapid development of medical science. According to the World Health Organization, for the period from 2015 to 2050, the number of people 60+ will increase from 900 million to 2 billion (from 12 to 22% in the total population of the world), that is, each 5th person will be over 60 years old. But is it possible to slow down even more or completely stop the aging process, and what is needed for this?

Place of publication:
New therapeutic journal Non Nocera, December, 2020

Resume:
asthenia (Greek “powerlessness”, “lack of strength”)-a protective-compensator reaction of the body to any state that threatens the exhaustion of energy resources, and by definition in ICD-10-“a constant sensation and/or complaints about a sense of general weakness, increased fatigue (with any type of load), as well as a decrease in working capacity in combination with 2 or more of the following complaints: muscle pain; headaches of tension; dizziness; sleep disturbances; dyspepsia; inability to relax; irritability".

Clinical manifestations of asthenic syndrome (AS) can be divided into:

• physical (muscle weakness, fatigue, exhaustion);

• emotional-psychological (emotional lability, irritability, a sense of internal tension, lowered mood background, apathetic);

• cognitive (decrease in mental performance, memory, concentration of attention);

• Sleep disorders (insomnia, drowsiness).

Place of publication:
New therapeutic magazine "Non Nocera", November, 2020

Summary:
arterial hypertension (AH) is an important medical and social problem around the world. The disease is often called the "silent killer" (English Silent Killer, since most patients are quite difficult to suspect the earliest symptoms of the lesions of target organs mediated by AH. Moreover, in patients with systolic blood pressure (garden)> 130 mm RT. Art. In the middle age, the risk of dementia in old age increases by 34%. According to the current clinical recommendations, the manifestations of the brain damage to AH are considered to be the so-called dumb (asymptomatic) lacunar heart attacks, hyperinathery changes in the white substance of the brain and cerebral micro-power, which are detected by magnetic resonance tomography (MRI). The clinical manifestation of brain damage as a target organ is cognitive impairment (KN). The recommendations for the treatment of patients from AH 2018 emphasize that MRI is an enough examination method, which does not allow it to use it for routine screening. However, neuroizualization, that is, an MRI, is necessary for patients with clinical signs of cognitive disorders (KF). Consequently, a competent and timely detection of cognitive complaints, signs of KN and their correction in patients with AH is an extremely important task for a doctor of any specialty.

Place of publication:
therapy No. 6 (40) 2020

Summary:
the purpose of the study is to evaluate the effectiveness, safety and the possibility of correcting the neuropsychiatric manifestations of chronic brain ischemia (chemical) drugs Mexidol ^® and Mexidol ^® Forte 250 within the framework of consecutive therapy against the background of arterial hypertension, atherosclerosis (IBS), osteoarthritis or OA) or OA) or OA) rheumatoid arthritis (RA). Material and methods. 134 patients 45–75 years old with a neuroimulated chemical chemicized, combined with hypertension, coronary heart disease and articular pathology were examined. Group 1 (observations) included 79 patients - 30 patients with RA (subgroup 1A) and 49 with the ot of the knee joints (subgroup 1b), who received in the complex therapy Mexidol ^® and Mexidol ^® Fort 250. Group 2 (control) amounted to 55 patients - 25 patients with RA (subgroup 2A) and 30 - with OA (subgroup 2B), which used to use basic therapy without the addition of Mexidol. The dynamics of subjective and physical symptoms were evaluated, values ​​on the scales of CGI, Mosa, MFI 20, anxiety and depression of Hamilton, Tinnetti. Mexidol ^® was prescribed intravenously (500 mg per day) for 14 days with the subsequent oral administration of the drug Mexidol ^® Fort 250 at 250 mg 3 times/day another 60 days. Results. ^® and Mexidol ^® to the standard treatment of drugs in the framework of consistent therapy contributed to an increasing improvement in all studied indicators. In the control groups, the cognitive status did not change. The use of initiating intravenous therapy with Mexidol increased the adherence of patients to the prolonged use of the drug. Conclusion. Violations of the locomotor function in polymorbid patients are partially associated with chemicals. The additional purpose of the consistent infusion and tablet forms of Mexidol significantly improves cognitive functions with the correction of the stability of walking, asthenic manifestations, and increases the motivation for active life. Key words: chronic brain ischemia, Mexidol ^® , Mexidol ^® Fort 250, osteoarthritis, rheumatoid arthritis, arterial hypertension, coronary heart disease.

Place of publication:
New therapeutic journal "Non Nocera" No. 4, 2019

Summary:
acute respiratory diseases or, as it is customary to name them, acute respiratory infections (Ori) is an urgent problem of modern medicine, especially during periods of sharp fluctuations in the temperature and humidity of the environment, when the traditionally expected incidence of influenza and other visual or mixtures increases sharply .

Place of publication:
therapeutic archive, 1, 2015

Summary:
the prevalence of diabetes (diabetes) of the 2nd type and metabolic disorders preceding it reached the scale of the epidemic. Oxidative stress plays a significant role in the development of micro- and macro-vascular complications in patients with diabetes. The accumulation of free radicals is responsible for the activation of pathological biochemical ways responsible for the development of systemic and vascular inflammation, endothelial dysfunction, hypercoagulation and ischemic conditions. Since damage to the vascular and nervous systems is not leveled even with adequate control of glycemia, comprehensive pathogenetic treatment strategies are needed. One of the mandatory components of the complex therapy of complications of diabetes is the use of antioxidant therapy using the drug Mexidol.