The experience of using Mexidol in the clinical practice of the therapist

Authors:
A.I. Martynov, MD, Professor, Academician of the Russian Academy of Sciences, Department of Hospital therapy No. 1 of the Faculty of Faculty of FSBEI in MGMSU named after A.I. Evdokimova
G.N. Gorokhovskaya, MD, professor, department of hospital therapy No. 1 of the medical faculty of FSBEI in MGMSU named after A.I. Evdokimova
V.L. Yun, Ph.D., assistant, department of internal diseases of the FSBEI dental faculty at MGMSU named after A.I. Evdokimova
M.M. Petina, Ph.D., head of the 2nd therapeutic department, therapist, KDC Medsi, Moscow
A.P. Kondrakhin, Ph.D., doctor - clinical pharmacologist, GBUZ GVV 2 DZM, Moscow
V.V. Toporkova, Ph.D., Cardiologist, AO MECSI-2 KDCP, Moscow
O.P. Nikolin, Ph.D., Associate Professor, Department of Hospital therapy No. 1 of the Faculty of Medicine FSBEI in MGMSU named after A.I. Evdokimova, Moscow

Place of publication: Polyclinic Journal / No. 5, 2023

The demographic situation of recent decades is characterized by an increase in the number of elderly and senile people, for which, due to age -related physiological characteristics, the development of chronic brain ischemia (Khim) is characteristic. Currently, Khim is 60–75% of all cerebrovascular diseases.
Ichechemic strokes in most cases develop against the background of chemical and are a factor leading to the growth of focal and diffuse ischemic or ischemic-depths of the brain that aggravate the course of chemical and accelerating the development of dementia in patients. With ischemia, there is a sharp increase in oxidative processes, which, in combination with the insufficiency of the antioxidant protection system, leads to oxidative stress. It is pathogenetically explainable to include antioxidant drugs in the therapy diagram, one of the bright representatives of which is the drug Mexidol with a convincing evidence base.
If you do not carry out treatment and not eliminate the excess of active forms of oxygen generated by ischemia, the cascade of reactions that cause chaotic (necrosis) or programmable (apoptosis) cell death is activated. The successful solution to this problem is feasible when providing medical workers with the necessary medical information.

Keywords: chronic brain ischemia, aging, elderly, senile age, oxidative stress, antioxidant effect, neuroprotection, Mexidol