Home \ Neurology \ Use of Mexidol in patients with mild (moderate) cognitive impairment: results of a meta-analysis

The use of Mexidol in patients with mild (moderate) cognitive disorders: the results of meta -analysis

Author:
V.V. ZAKHAROV, N.V. VAKHNINA
Federal State Autonomous Educational Institution of Higher Education “First Moscow State Medical University named after I.M. Sechenov” of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

Place of publication:
S.S. KORSAKOV JOURNAL OF NEUROLOGY AND PSYCHIATRY, 2024, Vol. 124, No. 1

Abstract:
The aim of the study was to conduct a meta-analysis of the effectiveness of Mexidol therapy in patients with chronic cerebral ischemia (CCI) and mild (moderate) cognitive impairment (CI).

Material and methods. This meta-analysis included the results of studies on the efficacy of Mexidol in CR, the severity of which was assessed using the MoCA scale. The pooled effect assessment included all publications on the results of independent clinical trials that provided efficacy assessment data using the MoCA scale at a level sufficient for further statistical analysis. The primary outcome of the meta-analysis was obtained for the final efficacy indicator values ​​in the groups of patients receiving Mexidol compared to the background therapy groups.

Results. The meta-analysis included the results of 10 prospective clinical trials of the efficacy of Mexidol in combination with background therapy in patients with CCI and mild (moderate) CR. The main group consisted of 482 patients, the comparison group – 455. Using the random effects statistical model, the effect size was 2.06 points, 95% CI for the difference in efficacy in the two groups – [0.98; 3.14 points] (p=0.0002).

Conclusion. A statistically significant improvement in cognitive function in patients with chronic cerebral ischemia was demonstrated with the use of Mexidol.

Key words: chronic cerebral ischemia, cognitive impairment, ethylmethylhydroxypyridine succinate, Mexidol, treatment.

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Actual

Results of an international multicenter, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of sequential therapy with ethylmethylhydroxypyridine succinate in patients in the acute and early recovery periods of ischemic stroke (IS)
Results of an international multicenter, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of sequential therapy with ethylmethylhydroxypyridine succinate in patients in the acute and early recovery periods of ischemic stroke (IS)
Cognitive disorders in the practice of a primary link: Focus for patients with arterial hypertension
Cognitive disorders in the practice of a primary link: Focus for patients with arterial hypertension
Resolution of the Council of Experts "The possibilities of neuroprotective therapy in patients with arterial hypertension and cognitive disorders"
Resolution of the Council of Experts "The possibilities of neuroprotective therapy in patients with arterial hypertension and cognitive disorders"
The results of an international multicenter randomized double-blind-controlled study of evaluating the effectiveness of the effectiveness and safety of consistent therapy of patients with chronic brain ischemia with Mexidol and Mexidol Forte 250 (study of Memo)
The results of an international multicenter randomized double-blind-controlled study of evaluating the effectiveness of the effectiveness and safety of consistent therapy of patients with chronic brain ischemia with Mexidol and Mexidol Forte 250 (study of Memo)
Reproduced drugs: Benefit ratio/risk
Reproduced drugs: Benefit ratio/risk
Treatment of patients with ischemic stroke in the vertebral-baslar system in the acute period: Experience in the use of the neuroprotective drug Mexidol
Treatment of patients with ischemic stroke in the vertebral-baslar system in the acute period: Experience in the use of the neuroprotective drug Mexidol
The effect of therapy with the drug Mexol on the regression of neurological deficiency and a functional outcome in patients with ischemic stroke: a systematic review and meta analysis
The effect of therapy with the drug Mexol on the regression of neurological deficiency and a functional outcome in patients with ischemic stroke: a systematic review and meta analysis
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Arterial hypertension and cognitive disorders. The gaze of a neurologist
The effectiveness of Mexidol in patients of different age groups with chronic brain ischemia with cognitive disorders (the results of subanalysis of the international multicenter randomized double blind placebo-controlled study of memes)
The effectiveness of Mexidol in patients of different age groups with chronic brain ischemia with cognitive disorders (the results of subanalysis of the international multicenter randomized double blind placebo-controlled study of memes)
The effectiveness and safety of Mexidol in patients of different age groups in the acute and early recovery periods of the hemisphere ischemic stroke (the results of subanarized a randomized double blind multicenter placebo-controlled in parallel groups of the study of epic)
The effectiveness and safety of Mexidol in patients of different age groups in the acute and early recovery periods of the hemisphere ischemic stroke (the results of subanarized a randomized double blind multicenter placebo-controlled in parallel groups of the study of epic)
The results of a multicenter dual blind randomized placebo-controlled clinical study on the assessment of the effectiveness and safety of the drug Mexidol in the treatment of attention deficit syndrome in children (mega)
The results of a multicenter dual blind randomized placebo-controlled clinical study on the assessment of the effectiveness and safety of the drug Mexidol in the treatment of attention deficit syndrome in children (mega)

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