Mexidol in the complex treatment of glaucoma

Author:
E.A. Egorov, N.G. Davydova, I.A. Romanenko, N.D. Novikova

RNIMU named after N.I. Pirogov, GB of GB named after Helmholtz, Moscow

Place of publication:
Clinical ophthalmology volume 12, No. 3, 2011

Summary:
the incidence of primary open-angle glaucoma (s) to this day is one of the most important medical and social problems. Glaucoma is one of the leading causes of blindness in developed countries, therefore, issues of improving the diagnosis and treatment of this disease are extremely relevant. The etiopathogenesis of glaucomas is complicated and, despite numerous studies, has not been fully studied. There is every reason to believe that it has a multifactor character. Glacker optical neuropathy (Gon) is due to the action of various factors leading to the apoptosis of the ganglion cells of the retina: with pressure of the optic nerve axons in the openings of the ethmoid plate due to increased intraocular pressure (IPD), impaired blood supply to the optic head, the formation of an excess of free radicals, in the way of ischemia and increased peroxidation of lipids (floor). With ischemia in the nervous tissue, protein synthesis is inhibition and the activation of anaerobic glycolysis, then the work of K-NA pumps and depolarization of cell membranes occurs. In response to this, a glutamate is released, which activates neurons through NMDA receptors, leading to an excessive amount of calcium ions into the cage. Excessively high concentration CA2+ in cells triggers the activation of complex nuclease cascades, protease and lipase. They directly affect intracellular proteins and lipids, as a result of which active free radicals are formed, as well as an excessive amount of nitrogen oxide (No), which can contribute to the development of the race. Various active forms of oxygen are formed, which have a cytotoxic effect on the retina, visual nerve, lead to destructive changes in the drainage system. In fact, mechanical and vascular factors realize their effects through metabolic processes.