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Possibilities of neurocytoprotheiation during reperfusion therapy

Authors:
I.A. Schukin1, 2, I.A. Koltsov1, 2, M.S. Fidler1, A.P. Glukhareva1

1FGAOU in Russian National Research Medical University named after N.I. Pirogov »Ministry of Health of Russia
(University Pirogov), Moscow, Russia;
2FGBU "Federal Center for Brain and Neurotechnology" of the Federal Medical and Biological Agency of Russia, Moscow, Russia

Place of publication: a journal of neurology and psychiatry named after S.S. Korsakova / vol. 124, No. 12, issue. 2, 2024

Summary of
acute cerebral circulation disorders (ONMK) occupy the second place among the causes of deaths and are the third most important cause of disability. In the structure of the ONMK, ischemic stroke (AI) takes first place. Damage to the substance of the brain during AI is a complex cascade of pathophysiological reactions, including neo -driving, oxidative stress, exaytotoxicity and apoptosis. One of the most actively developing areas of treatment of patients with AI is reperfusion therapy (RT). The use of neuroimagingalization-CT perfusion and MRI has significantly expanded the indications for the RT. One of the possible directions for expanding the capabilities of the Republic of Tatarstan is its joint use with neurocytoprotective therapy, which would increase the efficiency and safety of the RT. The review is devoted to research on the effectiveness of a combination of neurocytoprotheiation and TLT under AI.

Keywords: ischemic stroke, reperfusion therapy, thrombolytic therapy, mechanical thromboembolectomy, reperfusion damage, neuroprotection, cytoprotection, neurocytoprotheiation.
Information about the authors:
Schukin I.A. - https://orcid.org/0000-0002-6308–9706
I. Koltsov - https://orcid.org/0000-0002–9900-4073
Fidler M.S. - https://orcid.org/0000-0001-6464-521X
Glukhareva A.P. - https://orcid.org/0009-0004-4867–2102
Author responsible for correspondence: I. Schukin -E-mail: ivashchukin@gmail.com
how to quote:
Schukin I.A., Koltsov I.A., Fidler M.S., Glukhareva A.P. The possibilities of neurocytoprotext during reperfusion
therapy. Journal of neurology and psychiatry named after S.S. Korsakova. 2024; 124 (12 Issue 2): 75–88. https://doi.org/10.17116/jnevro202412412275

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The results of an international multicenter randomized double-blind-controlled study of evaluating the effectiveness of the effectiveness and safety of consistent therapy of patients with chronic brain ischemia with Mexidol and Mexidol Forte 250 (study of Memo)
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