The effect of Mexidol on changes in lipid phospholipid profile in acute cerebrovascular disorders in elderly patients

Author:
Yu.V. Abramenko

FSBEI in the Tver State Medical University of the Ministry of Health of Russia, Tver, Russia

Place of publication:
neurology, neuropsychiatry, psychosomatics. 2018, No. 10

Summary:
The purpose of the study is to assess the effectiveness of the inclusion of Mexidol in complex drug therapy in patients in the acute period of ischemic (AI) and hemorrhagic stroke. Patients and methods. 60 patients aged 60–74 years with a first -aimed stroke were examined: 34 of them were diagnosed with AI, in 26 - intra -core hemorrhage (Navy). The main group was 31 patients who received, in addition to therapy in accordance with the standards adopted in the Russian Federation, Mexidol. The comparison group included 29 patients who were prescribed only standard therapy. Before and against the background of intravenous drip administration of Mexidol, 500 mg for 10 days, indicators were assessed by the stroke scale of the American National Institute of Health (National Institutes of Health Stroke Scale, NiHSS), the Rivermide mobility index and the Rankin scale and the Bartel index. The percentage absorption of lipid phospholipid complexes in the infrared spectrum of blood serum was also investigated. The control group amounted to 20 practically healthy persons. Results and discussion. It was found that the dynamics of lipid phospholipid complexes of the blood serum correlate with the type of stroke. The inclusion of Mexidol in complex drug therapy in elderly patients in the acute period of AI and Navy contributed to the regression of focal neurological deficiency, improving daily activity and functional independence. Mexidol's reception had a positive effect on the level of phospholipids of neuronal membranes. Conclusion. Mexidol’s positive effect on the level of blood serum phospholipids was noted. The conclusion was made about the effectiveness of its inclusion in the complex therapy of the acute period of AI and hemorrhagic stroke, especially in the elderly. Key words: ischemic stroke; intracassium hemorrhage; therapy; Mexidol; phospholipids.