The role of oxidant stress in the development of vascular cognitive disorders

Author:
A.N. Bogolepova

FGAOU in Russian National Research Medical University named after N.I. Pirogov »Ministry of Health of Russia, Moscow, Russia;

FSBI "Federal Center for Brain and Neurotechnology" FMBA of Russia, Moscow, Russia

Place of publication:
a journal of neurology and psychiatry named after S.S. Korsakova 2020, T. 120, No. 8, S. 1-7

Summary:
Vascular cognitive disorders (TFR) are one of the urgent problems of clinical neurology and the second most common cause of dementia. TFR cover a number of disorders in which vascular factors cause or contribute to a decrease in cognitive functions. Among the main risk factors for the development of the Investigative Committee, elderly age and vascular factors are considered, leading to endothelial dysfunction and damage, which in turn can cause neurovascular dysfunction, increased permeability of the hematoencephalic barrier and microsyuded thrombosis. One of the most important mechanisms for the development of the Investigative Committee is oxidative stress, which indicates the need to use agents with antioxidant activity. Such drugs include Mexidol (ethylmethylhydroxypyridine succinate). Mexidol has pronounced antioxidant and antihypoxic properties. The clinical effectiveness of Mexidol in relation to the Investigative Committee was established in many studies. Key words: chronic cerebrovascular failure, oxidant stress, vascular cognitive impairment, endothelial dysfunction, Mexidol.