The results of the study of the effectiveness and safety of the use of Mexidol in patients with chronic brain ischemia

Author:
E.I. Chukanova, A.S. Chukanova, H.I. Mamaeva

GBOU VPO “Russian National Research Medical University named after N.I. Pirogov ", Moscow

Place of publication:
Journal of Neurology and Psychiatry, 2, 2015

Summary:
Purpose of the study. Analysis of the effectiveness and safety of the use of Mexidol and its impact on the dynamics of neurological manifestations of the disease, the emotional status and quality of life in patients with chronic brain ischemia (chemical). Material and methods. 45 patients with chemicals received Mexidol of 500 mg iv a drop 1 time per day for 14 days, followed by an oral reception of 500 mg (2 tablets 2 times a day) for 60 days. The comparison group consisted of 30 patients with chemicals, comparable by age, the presence of risk factors and the severity of neurological manifestations that did not accept Mexidol. Patients of both groups received basic therapy, including drugs to achieve the complete correction of their risk factors. Assessed the state of cognitive functions (MMSE questionnaire), motor activity, quality parameters (SF-36). Results. By the end of the study (on the 74th day), patients of the main group compared with the comparison group, the severity of motor activity disorders has significantly reduced, the indicator of the assessment with the recount of utility on the SF-36 scale was normalized, and a reliable improvement of the average indicators of the screening estimate of cognitive functions was noted (MMSE). When analyzing the results of the study, the high efficiency and safety of the treatment of patients with a chemous drug Mexidol was confirmed.