Features of the influence of Mexidol on the functional state of the central nervous system in patients who have suffered a stroke

Authors:
V.V. Kuznetsov, F.V. Yurchenko

Institute of Gerontology of AMNs of Ukraine, Kyiv

Place of publication:
Journal of Neurology and Psychiatry, 6, 2012

Summary:
in the structure of cerebrovascular pathology, the stroke occupies a leading place as one of the main causes of mortality and primary disability of the population. In the treatment of a stroke, in the acute period, measures are the measures to correct the impaired functions of the body and maintain the viability of the nervous tissue. In the recovery period, drugs are used that have an activating effect on neurotrophic and reparative processes, and secondary prophylaxis of stroke is carried out. It is known that brain ischemia is a multifactor pathological process that includes a decrease in energy products with a violation of active vehicles through cell membranes, excessive accumulation of excitoxic excitation mediators in brain structures, an increase in ionized calcium in neurons, hyperproduction of free radicals and activation of oxidant stress. To correct these changes, preparations with antihyplance and antioxidant properties are traditionally used, which include Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate). Mexidol improves the metabolism of nervous tissue, it is also known that it affects the rheological properties of blood, reduces platelet aggregation, and has a hypolipidemic effect.