Mexicular and combined therapy with Mexidol with young patients with cerebral angiodistonia

Authors:
E.N. Dyakonova, V.V. Makerova

FSBEI in "Ivanovo State Medical Academy" of the Ministry of Health of Russia, Ivanovo, Russia

Place of publication:
Journal of Neurology and Psychiatry, 8, 2018

Summary:
Purpose of the study. Assess the effect of mono- and combined therapy with Mexidol with young patients with cerebral angiodistonia. Material and methods. 90 patients (38 men and 52 women aged 25 to 44 years) were examined with vegetative dysfunction syndrome in the form of asthenovegetative and cephalgic syndromes taking Mexidol (1st group, 30 patients), Vinpocetin (2nd group, 30) and 30) and 30) and 30) and 30) and 30) Their combination (3rd group, 30). The condition of cerebral hemodynamics was evaluated using an algorithm for complex ultrasound examination, the state of autonomic regulation - by analyzing the variability of the heart rhythm, the functional state of microcirculation - by conducting a laser Doppler flower before and 10 days after the course of use of drugs. Results and conclusion. Mexidol in both mono and complex treatment of patients with cerebral angiodistonia possessed a vegetostabilizing, cerebrooprotective effect. An improvement in cerebral hemodynamics and microhemocirculation was revealed. As part of combined therapy (Mexidol and Vinpocetin), the effect of each drug was enhanced, and the adaptation of cerebral blood flow took place much faster than when using only winepocetine. Thus, the use of combined therapy (Mexidol and Vinpocetin) in patients with cerebrovascular pathology helps to minimize the negative prognosis of the development of the disease and may impede the development of acute cerebrovascular disorders. Keywords: Mexidol, Vinpocetin, microcirculatory disorders, autonomic dystonia, laser Doppler floometry, Cerebral angiodistonia.