Mexidol in the prevention of intracranial hypertension syndrome with the consequences of closed traumatic brain injury

Authors:
B.M. Doronin, A.Yu. Poyagin, O.B. Tyshkevich, V.B. Doronin

Novosibirsk State Medical University, Novosibirsk

Summary:
intracranial hypertension syndrome (HDG) with distant consequences of closed cranial injury (CSMT) is manifested by organic and functional disorders of varying degrees of severity. The work uses a method for assessing the degree of ICG by measuring distances between the structures of the brain stem using magnetic resonance imaging. The calculation of the restriction index of the posterior cranial fossa made it possible to compare the data of 96 patients with the HRG, some of which received Mexidol, and 28 healthy volunteers. Observation was carried out during the year with a neurological examination in dynamics. A comparison of groups of patients with each other and with indicators of healthy individuals revealed reliable differences expressed to a lesser extent of the NCH after treatment with Mexidol. The study showed that the prolonged course use of Mexidol is an effective method of preventing episodes of increasing intracranial pressure in the remote period of mild ZchMT and can be recommended for wide use both in stationary and outpatient conditions.