Treatment of patients with ischemic stroke in the vertebral-baslar system in the acute period: Experience in the use of the neuroprotective drug Mexidol

Authors:
Z.A. Goncharova, I.V. Chernikova, V.A. Nazarova, V.V. Tolmacheva, K.G. Ovsepyan
FSBEI in "Rostov State Medical University" of the Ministry of Health of Russia, Rostov-on-Don, Russia

Place of publication:
a journal of neurology and psychiatry named after S.S. Korsakova, 2024, T. 124, No. 2

Summary:
Purpose of the study. To evaluate the clinical efficiency and safety of the drug Mexidol in patients in the acute period of ischemic stroke in the vertebral-baslar system (IIVBS).

Material and methods. The open randomized comparative study was attended by 52 patients, of which 32 were received by Mexidol (main group, OG) and 20 - standard therapy without the use of neuroprotective drugs (comparison group). Assessment of the severity of the clinical manifestations of IIVBS was carried out using the Hoffenberth scale, the severity of the stroke was estimated on the NiHSS scale, the degree of disability of patients after the stroke used the Rankin scale, a neuropsychological study of patients was carried out using the Montreal scales for evaluating cognitive functions (MOCA), a hospital of anxiety and depression scale (depression ( HADS), asthenication scales (MFI-20), assessment of the quality of life of patients was carried out using the EQ-5D questionnaire.

Results. The use of Mexidol in the form of prolonged sequential therapy in patients of the OG led to a decrease in the severity of the clinical manifestations of IIVBS by 53.3%, a neurological deficit on the NIHSS scale by 59.5%. By the end of the course of therapy by Mexidol, 96.9% of patients coped with their own affairs without outside help, which was accompanied by the regression of emotional disorders and an increase in the quality of life of patients.

Conclusion. The early appointment of Mexidol in therapy of patients with IIVBS can be considered the most justified, since it contributes to an earlier and significant decrease in neurological deficiency and improve the quality of life of patients.

Keywords: cerebrovascular diseases, ischemic stroke in the vertebral-baslar system, vertebral-baslar failure, neuroprotective therapy, Mexidol.