The effectiveness and safety of the drug Mexol Forte 250 with sequential therapy of patients with chronic brain ischemia

Authors:
N.G. Kataeva ¹ , T.A. Zamoshchina ^1.2 , M.V. Svetlik ^1.2

¹ FSBEI in Siberian State Medical University Mini Health of Russia, Tomsk, Russia;
² FGAOU in National Research Tomsk State University, Tomsk, Russia

Place of publication:
a journal of neurology and psychiatry named after S.S. Korsakova, 2020, T. 120, No. 11

Summary:
Purpose of the study. Studying the effectiveness and safety of consistent therapy with Mexidol drugs (injections intravenously for 14 days - a saturation phase) and Mexidol Forte 250 (tablets for 60 days - the phase of maximization of the therapeutic effect) in patients with chronic brain ischemia (chemical) against the background of arterial hypertension and atherosclerosis. Material and methods. In the group of therapy with Mexidol, 27 patients were observed (24 women and 3 men) with Khim I-II century. Against the background of a combination of arterial hypertension and atherosclerosis, which is treated with Mexidol with the drug intravenously (500 mg once a day) for 14 days with the subsequent intake of Mexidol Forte 250 in a daily dose of 750 mg (1 tablet 3 times a day) for 60 days) . The comparison group consisted of 30 patients (22 women and 8 men) with KhMI I-II century, comparable by age, the nature of risk factors and the severity of neurological manifestations. Patients of both groups received basic therapy to correct their risk factors. They assessed the state of motor activity (Tinetti test), cognitive functions (MOCA Test), anxiety and depression (Hamilton's depression scale), a general clinical impression scale. Results and conclusion. The inclusion of Mexidol and Mexidol Forte 250 in the form of consistent prolonged therapy is the inclusion of chemical therapy in the standard therapy. The results indicate more clinical efficiency and sufficient safety of combined therapy. By the end of the study (on the 74th day), patients of the therapy group of Mexol with the drug, a reliable improvement in motor activity, cognitive functions of the emotional sphere, as well as a decrease in fatigue and neurological manifestations in comparison with a comparison group, was noted. Key words: chronic brain ischemia, Mexidol, Mexidol Forte 250.