The influence of Mexidol on the expression of the NRF2 transcription factor in the cortex of the large hemispheres of the brain with experimental ischemia

Authors:
E.N. Yakusheva, P.Yu. Mylnikov, I.V. Chernykh, A.V. Schulkin

FGBOU in the Ryazan State Medical University named after Acad. I.P. Pavlova "of the Ministry of Health of Russia, Ryazan, Russia

Place of publication:
Journal of Neurology and Psychiatry, 5, 2018

Summary:
Purpose of the study. To study the influence of the original domestic drug Mexidol on the expression of the transcription factor NRF2 in the cores of the cells of the frontal cerebral cortex with one -way occlusion of the general carotid artery. Material and methods. The work was done on 64 sexually mature rats of the Vistar line. The expression of NRF2 was determined by the immunohymic method. Results and conclusion. A single intra -Brushyne administration of Mexidol per 1 kg of body weight of the animal and its course oral administration per 1 kg of mass 3 times a day for 14 days did not affect the expression of the NRF2 factor. Unilateral occlusion of the general carotid artery increased the expression of NRF2 after 4 hours and on the 5th day after modeling occlusion. The oral administration of 100 mg of Mexidol per 1 kg of mass 3 times a day for 14 days before and after modeling ischemia increased the expression of NRF2 after 4 hours and on the 12th day compared to the norm indicators, as well as after 4 hours and on the 12th A day compared with the values ​​of the control of occlusion. Thus, it was established that Mexidol increases the expression of NRF2 in the frontal cortex of the rats of rats not in normal conditions, but with unilateral occlusion of the general carotid artery. Keywords: Mexidol, NRF2, ethylmethylhydroxypyridine succinate, ischemia, occlusion of the general carotid artery.