The influence of Mexidol on the expression of the factor induced by HIF-1α hypoxia in the cortex of the large hemispheres of the brain of rats with ischemia

Authors:
E.N. Yakusheva, P.Yu. Mylnikov, I.V. Chernykh, A.V. Schulkin

FGBOU in the Ryazan State Medical University named after Acad. I.P. Pavlova ", Ryazan, Russia

Place of publication:
Journal of Neurology and Psychiatry, 10, 2017

Summary:
Purpose of the study. To study the influence of Mexidol (ethylmethylhydroxypyridine of succinate) on the expression of the factor induced by hypoxia (HIF-1α), in the bark of the frontal lobe of the large hemispheres of the brain during its ischemia. Material and methods . The work was done on 64 sexually mature rats of the Vistar line. The expression of HIF-1α was determined immunohymic chemically. Results and discussion. It was established that a single intra-Brush administration of Mexidol at a dose of 120 mg/kg of mass and its course oral administration at a dose of 100 mg/kg of mass 3 times a day for 14 days does not affect the expression of the HIF-1α factor. Unilateral occlusion of the general carotid artery increases the expression of HIF-1α after 4 hours from the moment of occlusion. The oral introduction of Mexidol at a dose of 100 mg/kg of mass 3 times a day for 14 days before and after ischemia, increases the expression of HIF-1α after 4 and 12 hours compared with the norms of the norm on the 5th day compared to the values ​​of occlusion control. Thus, it was established that Mexidol increases the expression of HIF-1α in the frontal cortex of the rats of rats not in normal conditions, but with unilateral occlusion of the general carotid artery.