The role of oxidative stress in acute experimental hemorrhagic stroke and therapeutic effects of Mexidol

Authors:
T.A. Voronina, V.A. Kraneva, N.N. Zolotov, S.O. Kotelnikova, E.A. Waldman

FGBNU "Research Institute of Pharmacology named after V.V. Zakusova ”, Moscow, Russia

Place of publication:
a journal of neurology and psychiatry named after S.S. Korsakova, 2022, T. 122, No. 8, Issue. 2

Summary:
Purpose of the study. The study of the role of oxidative stress in the development of disorders that occur with hemorrhagic stroke (GI), and the assessment of the influence of Mexidol on neurological and cognitive disorders with the analysis of the relationship of therapeutic effects of the drug with its antioxidant effect. Material and methods. The study was carried out on sexually mature out-and-aids weighing 260–280 g. The Gi model was created by destruction of brain tissue in the Capsula Interna with the introduction of blood damage to the place. On the 1st, 7th and 14th day after the modeling of GI in rats, death, neurological deficit (McGrow scale, a rotating rod, TVS), convulsive syndrome, violation of cognitive functions were recorded, a quantitative analysis of the indicators of oxidative stress with the assessment of TBK-active (thiobarbituric acid - TBK) products in blood plasma and homogenates of the cortex of the brain of rats. Mexidol was introduced after surgery in the first 3 days at a dose of 150 mg/kg intra-abdominal, then (from 4 to 14 days)-75 mg/kg inward. Results. Mexol in rats with GI significantly increases survival, reduces the severity of the neurological deficit on the McGROW scale (manners, paresis of 1-4 limbs, paralysis of the lower extremities, lateral position), eliminates convulsive attacks, restores violation of movement coordination (TVS) and improves training processes and improves training processes and improves learning processes and improves memory. Mexidol normalizes the concentrations of TBK-active products in the blood of animals and homogenes of the cortex of the brain of rats 1 and 7 days after the GI. Conclusion. The data obtained indicate the role of oxidative stress in the development of violations with the GI and the ability of Mexidol to weaken the neurological deficit, convulsive manifestations and cognitive disorders for GI, which limits the manifestations of oxidative stress. All this substantiates the significance of the use of Mexidol in patients with GI and determines the features of its therapeutic effects. Key words: hemorrhagic stroke, intracerebral hematoma, oxidative stress, Mexidol, neurological deficit, convulsions, cognitive disorders.