The study of the influence of ethylmethylhydroxypyridine of succinate on the effectiveness of non -steroidal anti -inflammatory drugs with visceral and somatic pain in the experiment on mice and rats

Author:
E.A. Ivanova, A.G. Vasilchuk, A.I. Matyushkin, T.A. Voronin

FGBNU "Research Institute of Pharmacology named after V.V. Zakusova ”, Moscow, Russia

Place of publication:
a journal of neurology and psychiatry named after S.S. Korsakova, 2023, T. 123, No. 12

Summary:
Purpose of the study. To study the effect of ethyl-hydroxypyridine of the succinate (EMGPS) on the anti-Bolar effect of the non-election inhibitor of cyclooxygenase (COO) of the sodium diclofenac and selective chief-2 ethrioxib inhibitor on the models of acute visceral and somatic pain and evaluate the possibility of using EMGPS in combination with the inhibitors of the TSU for the reduction their doses with the preservation of anti -Bolar efficiency . Material and methods. The effect of EMGPS was studied with a single oral effect on anti-Bolar effects of non-steroidal anti-inflammatory drugs (NSAIDs): a non-melting inhibitor of the diclofenac sodium and selective TSOG-2-2 etrica inhibitor-on the models of acute visceral (vinegar croching test) and somatic pains (formalin tests the one Hyperalgesia with inflammation) in an experiment on mice and rats. Results. On the model of acute visceral pain in EMGPS mice (25–100 mg/kg) does not have a significant effect on its severity, but enhances the anti -Bolea effect of sodium diclofenac (0.5 mg/kg) and ethricoxib (1 mg/kg). In the formalin test in rats that simulates pain during operational cuts (injury), EMGPS (25 mg/kg) increases the severity of the anti -folly action of TSOG inhibitors (1 mg/kg) primarily due to a decrease in pain in the acute phase, due to the effect of formalin on afferent neurons . On the model of mechanical hyperalgesia in rats caused by exudative inflammation after injection of the Karraginan solution in the paw, the EMGPS enhances the effect of diclofenac to a greater extent than ethricoxib. Conclusion. The data obtained indicate the appropriateness of clinical study of the use of EMGPS in combination with NSAIDs for visceral and somatic pain in order to evaluate its ability to increase the therapeutic effect of NSAIDs. Keywords: ethylmethylhydroxypyridine succinate, non -steroidal anti -inflammatory drugs, visceral pain, somatic pain, mouse, rats.