Heroprotective effects of ethylmethylhydroxypyridine of succinate in an experimental study

Author:
T.A. Voronin

FGBNU "Research Institute of Pharmacology named after V.V. Zakusova ”, Moscow, Russia

Place of publication:
a journal of neurology and psychiatry named after S.S. Korsakova, 2020, T. 120, No. 4

Summary:
Purpose of the study. Studying the influence of Mexidol on cognitive and motor functions disturbed during aging, the threshold of convulsive reaction, body weight and life expectancy in the old rat smams of the Vistar line. Material and methods. In a long experiment, a violation of cognitive functions (a test of conditional reflex of passive avoidance), motor disorders (tests of a rotating rod and pulling on the crossbar), a convulsive threshold (a test of subcutaneous administration of the pentilentetrazole), an animal mass and life expectancy were evaluated in a long experiment. Mexidol in the form of a 0.15% solution that replaced drinking water, rats received 2 courses of 2 months: at the age of 18-20 and 22-24 months. The dose of Mexidol consumed by the rat was 40–75 mg/kg/day. Results. Mexol in the old rat smams of the Vistar line with prolonged course use improves training, preservation and reproduction of a memorable trace in the test of conditional reflex of passive avoidance, increases the convulsive threshold and improves muscle tone and coordination of movements disturbed during aging, and increases life expectancy. The use of Mexidol allows us to prevent a significant increase in body weight, characteristic of aging. Conclusion. Mexidol reduces the severity of the cognitive and neurological deficiency that occurs during aging in the rats of the Vistar line, increases the threshold of convulsive reaction and increases life expectancy, which is determined by its ability to influence mitochondrioogenesis and antioxidant properties. Keywords: aging, Mexidol, life expectancy, memory violation, neurological deficit, convulsive threshold.