Treatment of alcohol cancellation syndrome

Author:
Yu.P. Sivolap

FGBAOU VO "First Moscow State Medical University named after THEM. Sechenov "Ministry of Health of Russia (Sechenov University), Moscow, Russia

Place of publication:
a journal of neurology and psychiatry named after S.S. Korsakova, 2021, T. 121, No. 6

Summary:
the state of cancellation of alcohol develops with the refusal of drinking alcohol, after prolonged or short -lived, but their massive use, is manifested by somatic symptoms and, in some cases, is complicated by the development of alcoholic seizures, alcoholic hallucinosis and alcohol delirium, which can create a threat to patients. The leading neurochemical factors underlying alcohol cancellation and its complications are the insufficient cerebral content of the GABA and the excessive activity of glutamate, which matters to therapy. First -line preparations in the treatment of alcohol and alcoholic delirium cancellation are benzodiazepines with maximum pharmacological similarities with ethanol. As an alternative to benzodiazepines and in addition to them, especially in the case of protracted delirium with therapeutic resistance, other drugs, including barbiturates, antiepileptic drugs, propofols, dexemedetomidine and antipsychoticism, can be used. Certain prospects in the treatment of alcohol cancellation syndrome are associated with ethylmethylhydroxypyridine with a succinate, which has some pharmacological similarity with benzodiazepines. Key words: alcohol disorders, alcohol cancellation syndrome, alcohol convulsions, alcoholic hallucinosis, alcoholic delirium, benzodiazepines.