The effect of antioxidant therapy on some pathogenetic factors of primary open -angle glaucoma

Authors:
T.N. Malishevskaya ¹ , Yu.E. Filippova ²

¹ FSBI "National Medical Research Center of Eye Diseases named after Helmholtz »Ministry of Health of Russia, Moscow, Russia;
² GAUZ “Regional Ophthalmological Dispensary”, Tyumen, Russia

Place of publication:
Bulletin of ophthalmology, No. 4, t.139, 2023

Summary:
in patients with glaucoma, one of the main initiating mechanisms launching the chain of events, is a violation of the universal mechanism for regulating vascular tone due to endothelial dysfunction (ED). The main manifestation of the ED is the imbalance of vasoconstrictor and vasodilating endothelial mediators, the vastness of which triggers the mechanisms of adaptation distress, leading to the progression of morphological destruction, dyslipidemia, atherogenesis acucleration, the development of hemodynamic and hydrodynamic disorders. The drug Mexidol has a wide range of pharmacological activity, acting on the main pathogenetic links of the primary open -angle glaucoma (s). The purpose of the study. To study the vasomic, antioxidant and antihyplance effects of the drug Mexidol in patients with soup. Material and methods. The study includes 78 patients with the initial stage (n = 43) and the developed stage (n = 35), whose average age was 67.8 ± 1.5 years; 47 patients of the main group in addition to local hypotensive treatment were received by Mexidol, 31 patients compiled a control group. In comparison groups, the degree of ED was determined by the results of a sample with reactive hyperemia, investigated the level of stable metabolite of nitrogen oxide (ny2– nitrite) and endothelina-1 in blood plasma. The general assessment of oxidative stress was carried out by highly effective liquid chromatography. Studies of the functional activity of the retina were carried out using an electroretinograph and static computer perimetry according to the standard method. Results. Against the background of the use of Mexidol, in patients of the main group, the oscillator potential index is significantly increased, the inter-pertory latency decreases, the positive dynamics of perimetric indices, the improvement of the vascular endothelium in the sample with reactive hyperemia, the concentration of the Blood Plazm of the Mediator ET-1, and the moderate growth of nitrite are observed (NO2–) and a decrease in the bioactive vasotonic activity coefficient, the level of glutathioneperoxidase increases (p <0.05 compared to the initial value), the content of the spallic dyilladehyde is reduced, the lipid metabolism in patients of the main group (reducing the level of general cholesterol, low density lipoproteins, and low -density cholesterol, triglycerides, reduction of the atherogenic index compared to the initial value). Conclusion. Mexol's drug proved itself as an effective endothelioprotector, a powerful antioxidant and anti -enylaxant, contributed to a decrease in the factors of atherogenesis azecleization in patients with soup. Key words: primary open -angle glaucoma, endothelial dysfunction, Mexidol.