The use of Mexidol in the treatment of primary open -angle glaucoma

Authors:
I.A. Loskutov, O.M. Andryukhina, A.A. Kovrizhkina

Moscow Regional Research Clinical Institute. M.F. Vladimir

Place of publication:
Effective pharmacotherapy, 2022

Summary:
the article is devoted to the complex therapy of primary open -angle glaucoma, namely, the understanding of the principles of neuroprotection in the pathogenesis of the development of the glaucoma of optical neuropathy. Various biochemical reactions are described that are involved in the apoptosis of the layer of nerve fibers of the retina and the processes of neurodegeneration. In the Russian Federation, a reference (original) antioxidant with a multimodal mechanism of action of Mexidol (ethylmethylhydroxypyridine is actively used in the Russian Federation. Due to its unique complex molecule - the pyridine base and derivative of amber acid, Mexidol is characterized by high bioavailability and the ability to penetrate through the hematoencephalic barrier. The presence of succinate in the molecule also enhances the antioxidant effect, which fundamentally distinguishes the drug from other antioxidant analogues presented in the domestic pharmaceutical market. The mechanism of action of Mexidol is based on antioxidant, antihyplance and membrane effects. The use of Mexidol, which affects different links of oxidative stress, is justified in the complex treatment of primary open -angle glaucoma. It is no coincidence that the drug is included in the standards of medical care in patients with glaucoma. An analysis of a number of publications containing the results of studies of ethylmethylhydroxypyridine of succinate in the primary open-angle glaucoma of the I-III stages. A consistent scheme of therapy with Mexidol with proven effectiveness, slowing down the processes of neurodegeneration and stabilizing visual functions in patients with primary open -angle glaucoma, has been developed. Keywords: glaucoma, Mexidol, antioxidant, neuroprotection, oxidative stress.