The possibilities of increasing the effectiveness of patients with chronic brain ischemia against the background of Covid-19

Authors:
V.V. Kovalchuk, I.I. Ershova, N.V. Molodovskaya

St. Petersburg GBUZ "City Hospital No. 38 named after N.A. Semashko ", St. Petersburg, Russia

Place of publication:
a journal of neurology and psychiatry named after S.S. Korsakova, 2021, T. 121, No. 3, Issue. 2

Summary:
Purpose of the study. Studying the possibility of increasing the effectiveness of treatment of patients with chronic brain ischemia (HIGM) against the background of COVID-19 using the drug Mexidol. Material and methods. 304 patients with HIGM and Covid-19 were observed; The 1st group (n = 152) was compiled by patients who received basic therapy and Mexidol, the 2nd group (n = 152)-received only basic therapy. For 14 days, Mexidol was prescribed intravenously with a drop of 500 mg (10 ml) per 400 ml of physiological solution, then Mexol Forte 250 was prescribed 250 mg 3 times a day for 2 months. They evaluated the state of cognitive functions (Mosa scale), sleep (Spiegel questionnaire), asthenia (MFI-20 scale), quality of life (SIP questionnaire). The examination was carried out before the start of treatment, 30 and 75 days after its beginning. Results. Patients of the 1st group took place: a more complete and early restoration of the state of cognitive functions (an increase in indicators on the Mosa scale, p <0.01), astress regression (p <0.05), normalization of sleep (p <0.01) . Among patients of the 1st group, the end of the study turned out to be reliably more patients with complete or significant restoration of all indicators of the quality of life. Conclusion. Long-term sequential therapy with Mexidol with the drug provides a more complete restoration of impaired functions in patients with HIGM and Covid-19. Key words: Covid-19, SARS-COV-2 virus, chronic brain ischemia, asthenia, cognitive disorders, dementia, quality of life, Mexidol.