The experience of using Mexidol in the clinical practice of the therapist

Authors:
MARTYNOV A.I., MD, Professor, Academician of the Russian Academy of Sciences, Department of Hospital Therapy No. 1, Faculty of Medicine,
A.I. Evdokimov Moscow State Medical University of the Russian Academy of Sciences GOROKHOVSKAYA G.N., MD, Professor, Department of Hospital Therapy No. 1, Faculty of Medicine, A.I. Evdokimov
Moscow State Medical University of the Russian Academy of Sciences YU.N. V.L., MD, PhD, Assistant, Department of Internal Diseases, Faculty of Dentistry, A.I. Evdokimova
PETINA M.M., candidate of medical sciences, head of the 2nd therapeutic department, general practitioner, CDC MEDSI, Moscow
KONDRAKHINA A.P., candidate of medical sciences, clinical pharmacologist, GBUZ GVV 2 DZM, Moscow
TOPORKOVA V.V., candidate of medical sciences, cardiologist, JSC MEDSI-2 KDCP, Moscow
NIKOLIN O.P., Ph.D., Associate Professor, Department of Hospital Therapy No. 1, Faculty of Medicine, Federal State Budgetary Educational Institution of Higher Education MGMSU named after. A.I. Evdokimova, Moscow

Place of publication: Poliklinika Magazine / No. 5, 2023

The demographic situation of recent decades has been characterized by an increase in the elderly and senile population, who, due to age-related physiological characteristics, are prone to the development of chronic cerebral ischemia (CCI). Currently, CCI accounts for 60-75% of all cerebrovascular diseases.
Ischemic strokes in most cases develop in the context of CCI and are a factor leading to the aggravation of focal and diffuse ischemic or ischemic-degenerative changes in the brain, aggravating the course of CCI and accelerating the development of dementia in patients. During ischemia, oxidative processes sharply increase, which, combined with a deficiency in the antioxidant defense system, leads to oxidative stress. Pathogenetically, it is understandable to include antioxidant drugs in the treatment regimen for CCI, a prominent example of which is Mexidol, a drug with a compelling evidence base.
If left untreated and the excess reactive oxygen species generated during ischemia are not eliminated, a cascade of reactions is activated, causing either chaotic (necrosis) or programmed (apoptosis) cell death. Successful resolution of this problem is possible by providing healthcare professionals with the necessary treatment information.

Key words: chronic cerebral ischemia, aging, elderly, old age, oxidative stress, antioxidant effect, neuroprotection, Mexidol