Home \ Neurology \ Possibilities of neurocytoprotection during reperfusion therapy

Possibilities of neurocytoprotheiation during reperfusion therapy

Authors:
SHCHUKIN I.A. 1*, 2*, KOLTSOV I.A. 1*, 2*, FIDLER M.S. 1*, GLUKHAREVA A.P. 1*

1* Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
(Pirogov University), Moscow, Russia;
2* Federal Center for Brain and Neurotechnology of the Federal Medical and Biological Agency of Russia, Moscow, Russia

Place of publication: S.S. Korsakov Journal of Neurology and Psychiatry / Vol. 124, No. 12, Issue 2, 2024

Abstract:
Acute cerebrovascular accidents (CVA) are the second leading cause of death and the third leading cause of disability. Ischemic stroke (IS) is the leading cause of CVA. Brain damage in IS involves a complex cascade of pathophysiological reactions, including neuroinflammation, oxidative stress, excitotoxicity, and apoptosis. Reperfusion therapy (RT) is one of the most rapidly developing treatments for patients with IS. The use of neuroimaging, such as CT perfusion and MRI, has significantly expanded the indications for RT. One potential avenue for expanding the capabilities of RT is its combined use with neurocytoprotective therapy, which could improve its efficacy and safety. This review focuses on studies evaluating the effectiveness of the combination of neurocytoprotection and TLT in patients with IS.

Keywords: ischemic stroke, reperfusion therapy, thrombolytic therapy, mechanical thromboembolectomy, reperfusion injury, neuroprotection, cytoprotection, neurocytoprotection.
Author information:
Shchukin I.A. — https://orcid.org/0000-0002-6308-9706
Koltsov I.A. — https://orcid.org/0000-0002-9900-4073
Fidler M.S. — https://orcid.org/0000-0001-6464-521X
Glukhareva A.P. — https://orcid.org/0009-0004-4867-2102
Corresponding author: Shchukin I.A. — e-mail: ivashchukin@gmail.com
How to cite:
Shchukin I. A., Koltsov I. A., Fidler M. S., Glukhareva A. P. Possibilities of neurocytoprotection during reperfusion
therapy. Korsakov Journal of Neurology and Psychiatry. 2024; 124 (12 issue 2): 75–88. https://doi.org/10.17116/jnevro202412412275

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Actual

Results of an international multicenter, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of sequential therapy with ethylmethylhydroxypyridine succinate in patients in the acute and early recovery periods of ischemic stroke (IS)
Results of an international multicenter, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of sequential therapy with ethylmethylhydroxypyridine succinate in patients in the acute and early recovery periods of ischemic stroke (IS)
Cognitive disorders in the practice of a primary link: Focus for patients with arterial hypertension
Cognitive disorders in the practice of a primary link: Focus for patients with arterial hypertension
Resolution of the Council of Experts "The possibilities of neuroprotective therapy in patients with arterial hypertension and cognitive disorders"
Resolution of the Council of Experts "The possibilities of neuroprotective therapy in patients with arterial hypertension and cognitive disorders"
The results of an international multicenter randomized double-blind-controlled study of evaluating the effectiveness of the effectiveness and safety of consistent therapy of patients with chronic brain ischemia with Mexidol and Mexidol Forte 250 (study of Memo)
The results of an international multicenter randomized double-blind-controlled study of evaluating the effectiveness of the effectiveness and safety of consistent therapy of patients with chronic brain ischemia with Mexidol and Mexidol Forte 250 (study of Memo)
Reproduced drugs: Benefit ratio/risk
Reproduced drugs: Benefit ratio/risk
Treatment of patients with ischemic stroke in the vertebral-baslar system in the acute period: Experience in the use of the neuroprotective drug Mexidol
Treatment of patients with ischemic stroke in the vertebral-baslar system in the acute period: Experience in the use of the neuroprotective drug Mexidol
The use of Mexidol in patients with mild (moderate) cognitive disorders: the results of meta -analysis
The use of Mexidol in patients with mild (moderate) cognitive disorders: the results of meta -analysis
The effect of therapy with the drug Mexol on the regression of neurological deficiency and a functional outcome in patients with ischemic stroke: a systematic review and meta analysis
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Arterial hypertension and cognitive disorders. The gaze of a neurologist
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The effectiveness of Mexidol in patients of different age groups with chronic brain ischemia with cognitive disorders (the results of subanalysis of the international multicenter randomized double blind placebo-controlled study of memes)
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The effectiveness and safety of Mexidol in patients of different age groups in the acute and early recovery periods of the hemisphere ischemic stroke (the results of subanarized a randomized double blind multicenter placebo-controlled in parallel groups of the study of epic)
The effectiveness and safety of Mexidol in patients of different age groups in the acute and early recovery periods of the hemisphere ischemic stroke (the results of subanarized a randomized double blind multicenter placebo-controlled in parallel groups of the study of epic)
The results of a multicenter dual blind randomized placebo-controlled clinical study on the assessment of the effectiveness and safety of the drug Mexidol in the treatment of attention deficit syndrome in children (mega)
The results of a multicenter dual blind randomized placebo-controlled clinical study on the assessment of the effectiveness and safety of the drug Mexidol in the treatment of attention deficit syndrome in children (mega)

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