Oxidative stress in the pathogenesis of cerebral stroke and its correction

Authors:
M.Yu. MARTYNOV^1,2, M.V. ZHURAVLEVA^3.4, N.S. VASYUKOVA⁵, E.V. KUZNETSOVA⁶, T.R. KAMENEVA⁷

¹FGAOU in Russian National Research Medical University named after N.I. Pirogov »Ministry of Health of Russia, Moscow, Russia;

²FSBI "Federal Center for Brain and Neurotechnology" of the Federal Medical and Biological Agency of Russia, Moscow, Russia;

³FSBI “Scientific Center for Expertise of Medical Application” of the Ministry of Health of Russia, Moscow, Russia;

⁴FGAOU in "First Moscow State Medical University named after THEM. Sechenov ”of the Ministry of Health of Russia (Sechenov University), Moscow, Russia;

⁵FGBNU "Federal Scientific Center-the All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K.I. Scriabin and Ya.R. Kovalenko of the Russian Academy of Sciences ”, Moscow, Russia;

⁶GBU "Research Institute of Health and Medical Management" of the Department of Health of Moscow, Moscow, Russia;

⁷GBUZ "City Clinical Hospital named after M.P. Konchalovsky "Department of Health of Moscow, Moscow, Russia

Place of publication:
S.S. KORSAKOV JOURNAL OF NEUROLOGY AND PSYCHIATRY, 2023, Vol. 123, No. 1

Abstract:
The importance of oxidative stress (OS) in the pathogenesis of ischemic (IS) and hemorrhagic (HI) stroke is examined. Its role in the development of programmed cell death, increased blood-brain barrier permeability, activation of astro- and microglia, and local inflammation is demonstrated. Issues of neuro- and cytoprotection and their translation into clinical practice are considered. Examples of experimental and clinical studies demonstrate the effectiveness of prolonged administration of the multimodal neurocytoprotector with antioxidant action, ethylmethylhydroxypyridine succinate (Mexidol), in the acute and early recovery periods of IS and HI.

Key words: stroke, reperfusion, oxidative stress, programmed cell death, apoptosis, ferroptosis, hemoglobin, neuroprotection, ethylmethylhydroxypyridine succinate, Mexidol.