Home \ Neurology \ The effectiveness of Mexidol in transient ischemic attacks in the vertebrobasilar system in elderly patients with chronic cerebral ischemia

The effectiveness of Mexidol with transient ischemic attacks in the vertebral-baslar system in elderly patients with chronic brain ischemia

Author:
Yu. V. ABRAMENKO

FSBEI in the Tver State Medical University of the Ministry of Health of Russia, Tver, Russia

Place of publication:
JOURNAL OF NEUROLOGY AND PSYCHIATRY, 9, 2018; Issue 2

Abstract:
Objective of the study. To study the clinical efficacy, metabolic and membrane-protective effects of mexidol in transient ischemic attacks (TIA) in the vertebrobasilar system (VBS) in elderly patients with chronic cerebral ischemia (CCI). Material and methods. Fifty-three patients aged 60 to 74 years with the first episode of TIA in the VBS against the background of CCI were examined. The main group included 33 patients who received mexidol (500 mg for 10 days) in addition to standard therapy. The comparison group consisted of 20 patients who received only standard therapy. We studied the dynamics of clinical manifestations of TIA, indicators of the oxidant and antioxidant systems, as well as the percentage absorption of lipid-phospholipid complexes of blood serum in the infrared spectrum. The control group consisted of 20 practically healthy patients. Results and conclusion. The use of Mexidol is associated with more rapid regression of focal neurological deficits. The drug significantly reduced the intensity of lipid peroxidation and had a positive effect on the level of neuronal membrane phospholipids. The identified metabolic and membrane-protective effects of Mexidol, as well as its positive impact on the regression of focal neurological deficits, justify its inclusion in the complex therapy of transient ischemic attack (TIA) in the vertebrobasilar system (VBS) associated with chronic cerebral ischemia, especially in elderly patients. Keywords: transient ischemic attack, vertebrobasilar system, chronic cerebral ischemia, Mexidol, lipid peroxidation, phospholipids.

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Actual

Results of an international multicenter, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of sequential therapy with ethylmethylhydroxypyridine succinate in patients in the acute and early recovery periods of ischemic stroke (IS)
Results of an international multicenter, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of sequential therapy with ethylmethylhydroxypyridine succinate in patients in the acute and early recovery periods of ischemic stroke (IS)
Cognitive disorders in the practice of a primary link: Focus for patients with arterial hypertension
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Resolution of the Council of Experts "The possibilities of neuroprotective therapy in patients with arterial hypertension and cognitive disorders"
Resolution of the Council of Experts "The possibilities of neuroprotective therapy in patients with arterial hypertension and cognitive disorders"
The results of an international multicenter randomized double-blind-controlled study of evaluating the effectiveness of the effectiveness and safety of consistent therapy of patients with chronic brain ischemia with Mexidol and Mexidol Forte 250 (study of Memo)
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Reproduced drugs: Benefit ratio/risk
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Arterial hypertension and cognitive disorders. The gaze of a neurologist
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The effectiveness of Mexidol in patients of different age groups with chronic brain ischemia with cognitive disorders (the results of subanalysis of the international multicenter randomized double blind placebo-controlled study of memes)
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The effectiveness and safety of Mexidol in patients of different age groups in the acute and early recovery periods of the hemisphere ischemic stroke (the results of subanarized a randomized double blind multicenter placebo-controlled in parallel groups of the study of epic)
The effectiveness and safety of Mexidol in patients of different age groups in the acute and early recovery periods of the hemisphere ischemic stroke (the results of subanarized a randomized double blind multicenter placebo-controlled in parallel groups of the study of epic)
The results of a multicenter dual blind randomized placebo-controlled clinical study on the assessment of the effectiveness and safety of the drug Mexidol in the treatment of attention deficit syndrome in children (mega)
The results of a multicenter dual blind randomized placebo-controlled clinical study on the assessment of the effectiveness and safety of the drug Mexidol in the treatment of attention deficit syndrome in children (mega)

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