The effect of mexidol on changes in the lipid-phospholipid profile in acute cerebrovascular accidents in elderly patients

Author:
Yu.V. Abramenko

FSBEI in the Tver State Medical University of the Ministry of Health of Russia, Tver, Russia

Place of publication:
NEUROLOGY, NEUROPSYCHIATRY, PSYCHOSOMATICS. 2018, No. 10

Abstract:
The aim of the study was to evaluate the efficacy of incorporating Mexidol into combination drug therapy in patients with acute ischemic (IS) and hemorrhagic stroke. Patients and methods. Sixty patients aged 60–74 years with first-time hemispheric stroke were examined: 34 of them were diagnosed with IS, and 26 with intracerebral hemorrhage (ICH). The study group consisted of 31 patients who received Mexidol in addition to therapy in accordance with the standards adopted in the Russian Federation. The comparison group included 29 patients who were prescribed standard therapy alone. Before and during intravenous infusion of 500 mg Mexidol for 10 days, the National Institutes of Health Stroke Scale (NIHSS), Rivermead Mobility Index, modified Rankin Scale, and Barthel Index were assessed. Also, the percentage absorption of lipid-phospholipid complexes in the infrared spectrum of blood serum was studied. The control group consisted of 20 practically healthy individuals. Results and discussion. It was found that the dynamics of lipid-phospholipid complexes in blood serum correlates with the type of stroke. The inclusion of Mexidol in the complex drug therapy of elderly patients in the acute period of ischemic stroke and intracerebral hemorrhage contributed to the regression of focal neurological deficit, improvement of daily activity and functional independence. Mexidol intake had a positive effect on the level of phospholipids in neuronal membranes. Conclusion. A positive effect of Mexidol on the level of phospholipids in blood serum was noted. A conclusion was made about the effectiveness of its inclusion in the complex therapy of the acute period of ischemic stroke and hemorrhagic stroke, especially in the elderly. Key words: ischemic stroke; intracerebral hemorrhage; therapy; Mexidol; phospholipids.