Mono- and combination therapy with Mexidol in young patients with cerebral angiodystonia

Authors:
E.N. DYAKONOVA, V.V. MAKEROVA

Federal State Budgetary Educational Institution of Higher Education "Ivanovo State Medical Academy" of the Ministry of Health of the Russian Federation, Ivanovo, Russia

Place of publication:
JOURNAL OF NEUROLOGY AND PSYCHIATRY, 8, 2018

Abstract:
Objective of the study. To evaluate the effect of mono- and combination therapy with Mexidol in young patients with cerebral angiodystonia. Material and methods. A total of 90 patients (38 men and 52 women aged 25 to 44 years) with autonomic dysfunction syndrome in the form of asthenovegetative and cephalgic syndromes were examined. They received Mexidol (Group 1, 30 patients), vinpocetine (Group 2, 30), and their combination (Group 3, 30). Cerebral hemodynamics was assessed using a comprehensive ultrasound examination algorithm, autonomic regulation — by analyzing heart rate variability, and the functional state of microcirculation — by laser Doppler flowmetry before and 10 days after the course of drug administration. Results and conclusion. Mexidol, used both as a monotherapy and in combination therapy, had a vegetative-stabilizing and cerebroprotective effect in patients with cerebral angiodystonia. Improvements in cerebral hemodynamics and microcirculation were observed. When used in combination therapy (Mexidol and vinpocetine), the effect of each drug was enhanced, with cerebral blood flow adaptation occurring significantly faster than with vinpocetine alone. Thus, the use of combination therapy (Mexidol and vinpocetine) in patients with cerebrovascular pathology helps minimize the negative prognosis for the disease and may prevent the development of acute cerebrovascular accident. Keywords: Mexidol, vinpocetine, microcirculatory disorders, autonomic dystonia, laser Doppler flowmetry, cerebral angiodystonia.