Correction of pathological conditions caused by insulin-resisted hyperglycemia

Authors:

E.Yu. Solovyova*, A.N. Karneev, E.A. Tyutyumova

*GBOU VPO “Russian National Research Medical University named after N.I. Pirogov ", Moscow, Russia

 

A high level of glucose in the blood with a hypoxic-ischemic state is one of the main factors that determine the degree of brain damage. The consequence of a hyperglycemic-ischemic state is an increase in the formation of active forms of oxygen and impaired functioning of the endogenous antioxidant system. To compensate for the forming cerebrovascular disorders against the background of a combination of ischemia and diabetes, drug treatment must be used. The most effective tools are antioxidants from the group of
2-ethyl-6-methyl-3-oxypyrididine derivatives.
Key words: brain ischemia, phospholipids, phosphatidylcholine, diabetes mellitus, neuropathy, free radicals.

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