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Neuroprotective therapy with age -related macular degeneration

Authors:
VLASOVA A.S. 1*, PETROV S.A. 1*, 2*, RENZYAK E.V. 1*, 3*

1* West Siberian Institute of Postgraduate Medical Education, Tyumen, Russia;
2* Tyumen Scientific Center of the Siberian Branch of the Russian Academy of Sciences, Tyumen, Russia;
3* Khanty-Mansiysk Autonomous Okrug - Yugra District Clinical Hospital, Khanty-Mansiysk, Russia

Place of publication: Bulletin of Ophthalmology / Vol. 140, No. 6, 2024

ABSTRACT:
Age-related macular degeneration (AMD) is a chronic, multifactorial degenerative eye disease considered one of the leading causes of irreversible blindness worldwide. Despite numerous studies, there is no consensus regarding the predominant pathological mechanism leading to photoreceptor loss. AMD is a disease characterized by molecular and cellular abnormalities that ultimately lead to photoreceptor degeneration. This review article presents data from international and Russian researchers studying the pathophysiological mechanisms of the development and progression of photoreceptor degeneration, outlines scientific developments regarding modern therapeutic approaches to correcting these disorders, and presents promising approaches to drug-based neuroretinoprotection that require confirmation in clinical trials.

Key words: age-related macular degeneration, neuroprotection, retinoprotection, peptide bioregulators, antioxidants, ethylmethylhydroxypyridine succinate.

AUTHORS INFORMATION:
Vlasova A.S. — https://orcid.org/0000-0002-6835-3393
Petrov S.A. — https://orcid.org/0000-0002-1566-2299
Renziak E.V. — https://orcid.org/0009-0007-2258-2207
Corresponding author: Vlasova Anastasia Sergeevna — e-mail: okula-83@mail.ru
HOW TO CITE:
Vlasova A.S., Petrov S.A., Renziak E.V. Neuroprotective therapy for age-related macular degeneration. Bulletin of ophthalmology. 2024;140(6):152–158. https://doi.org/10.17116/oftalma2024140061152

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