The systemic stressful effect of Mexidol in chronic brain ischemia

Authors:

Antipenko E.A.1*, Deryugina A.V. 2*, Gustov A.V.1*

1*GBOU VPO Nizhny Novgorod State Medical Academy of the Ministry of Health of Russia, Nizhny Novgorod;

2*National Research University "Nizhny Novgorod State University named after N.I. Lobachevsky ”, Nizhny Novgorod

The purpose of the study.

To clarify the mechanisms of the anti -stress effect of the antioxidant drug (Mexidol) in patients with chronic brain ischemia (Khim). Material and methods. 67 patients with chemicals, 48 ​​women and 19 men, the average age 48.2 years observed. To assess the state of a multi -level stress system, they studied: the level of anxiety and depression, the degree of vegetative imbalance, adaptive blood reactions and the functional properties of red blood cell membranes, the level of medium mass molecules in the blood plasma. Therapeutic complexes included standard therapy and Mexidol of 500 mg (10 ml) intravenously by a drop of 200 ml of physiological solution 1 time per day for 10 days with the subsequent transition to the oral intake of 1 tablet (125 mg) 3 times a day for 3 months. Results and conclusion. In the group of patients receiving Mexidol, a more pronounced and prolonged positive effect on the clinical symptoms of chemicals was noted. These patients had a persistent decrease in anxiety, a decrease in vegetative imbalance. The dynamics of adaptive blood reactions indicated the activation of the function of the adrenal cortex. There was a decrease in the content of the level of medium mass molecules and the restoration of the sorption capacity of ER Itrocytes. The results indicate a multicomponent multi -level stressful effect of Mexidol in patients with chronic brain ischemia.

Key words: Mexidol, chronic brain ischemia, treatment, stress.