The systemic stressful effect of Mexidol in chronic brain ischemia

Authors:

Antipenko E.A.1*, Deryugina A.V. 2*, Gustov A.V.1*

1*GBOU VPO Nizhny Novgorod State Medical Academy of the Ministry of Health of Russia, Nizhny Novgorod;

2*National Research University "Nizhny Novgorod State University named after N.I. Lobachevsky ”, Nizhny Novgorod

Place of publication:

Journal of Neurology and Psychiatry, 4, 2016

The purpose of the study.

To clarify the mechanisms of the anti-stress effect of the antioxidant drug (mexidol) in patients with chronic cerebral ischemia (CCI). Material and methods. We observed 67 patients with CCI, 48 women and 19 men, average age 48.2 years. To assess the state of the multilevel stress system, the following were studied: the level of anxiety and depression, the degree of vegetative imbalance, adaptive blood responses and the functional properties of erythrocyte membranes, the level of medium-weight molecules in blood plasma. The therapeutic complexes included standard therapy and mexidol 500 mg (10 ml) intravenously by drip in 200 ml of saline solution once a day daily for 10 days, followed by a transition to oral administration of the drug 1 tablet (125 mg) 3 times a day for 3 months. Results and conclusion. In the group of patients receiving mexidol, a more pronounced and long-lasting positive effect on the clinical symptoms of CCI was noted. These patients experienced a persistent reduction in anxiety levels and a reduction in autonomic imbalance. The dynamics of adaptive blood responses indicated activation of adrenal cortex function. A decrease in medium-weight molecule levels and a restoration of red blood cell sorption capacity were observed. These results demonstrate the multicomponent, multilevel stress-limiting effect of Mexidol in patients with chronic cerebral ischemia.

Key words: Mexidol, chronic cerebral ischemia, treatment, stress.