Oxidative stress and its drug correction by Mexidol with traumatic brain injury

Author:
N.V. GOVOROVA

State Budgetary Educational Institution of Higher Professional Education "Omsk State Medical Academy of the Ministry of Health", Omsk, Russia

Place of publication:
EMERGENCY MEDICAL CARE, 2, 2013

Abstract:
One hundred and fourteen patients with isolated severe traumatic brain injury aged 18 to 55 years were examined and treated. Group I included 61 surviving patients, group II - 53 patients who died on the 3rd-15th days of the post-traumatic period. Patients of groups I and II received complex intensive therapy according to the current protocols. Fifteen patients (subgroup I) received Mexidol as part of complex therapy at a dose of 1200 mg / day for 7-10 days. With the use of Mexidol, the intensity of lipid peroxidation processes decreased, the power of the cellular antioxidant defense system was maintained at a sufficient level, earlier resolution of post-traumatic encephalopathy and recovery of consciousness were observed. With treatment with Mexidol, a more favorable course of the early post-traumatic period and a decrease in complications were noted (χ2 = 55.4; p