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Morphofunctional foundations of the development of vascular cognitive and emotional disorders

Author:

Zhitkova Yu.V.

The purpose of the study is to study the state of cerebrovascular reactivity (CVR) and structural changes in the substance of the brain in patients with moderate cognitive disorders.

Patients and methods. 385 patients aged 57 to 79 years with moderate vascular cognitive disorders (SKN) were examined. The relationship of clinical variants of SKN and depression with the volume and localization of ischemic damage to the brain substance, as well as with the state of CVR in various vascular pools at the stage of inclusion in the study and after 20 months, has been studied.

Results. The connection of the neuropsychological profile and the severity of the SKN with the features of structural damage to the substance of the brain was revealed, but to a greater extent with a decrease in the CVR in the carbon arteries (SA) system and a combined decrease in the CVR in the CA and the verteba -basial basin (VBB). The association of the frequency of development of depression with the localization of ischemic damage in the frontal lobes and a decrease in the CVR in CA on the left, as well as a combined decrease in the CVR and VBB, has been established.

Conclusion. The state of the CVR, determined in various vascular pools, can serve as an early prognostic sign of developing SKN or depression.

Key words: vascular cognitive impairment; cognitive and emotional disorders; Cerebrovascular reactivity.

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The results of an international multicenter randomized double-blind-controlled study of evaluating the effectiveness of the effectiveness and safety of consistent therapy of patients with chronic brain ischemia with Mexidol and Mexidol Forte 250 (study of Memo)
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The effectiveness and safety of Mexidol in patients of different age groups in the acute and early recovery periods of the hemisphere ischemic stroke (the results of subanarized a randomized double blind multicenter placebo-controlled in parallel groups of the study of epic)
The effectiveness and safety of Mexidol in patients of different age groups in the acute and early recovery periods of the hemisphere ischemic stroke (the results of subanarized a randomized double blind multicenter placebo-controlled in parallel groups of the study of epic)
Resolution of the Council of Experts "The possibilities of neuroprotective therapy in patients with arterial hypertension and cognitive disorders"
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