Home \ Neurology \ Morphofunctional bases of the development of vascular cognitive and emotional disorders

Morphofunctional foundations of the development of vascular cognitive and emotional disorders

Author:

Zhitkova Yu.V.

Place of publication:

Neurology, neuropsychiatry, psychosomatics. 2017

The aim of the study is to investigate the state of cerebrovascular reactivity (CVR) and structural changes in brain tissue in patients with mild cognitive impairment.

Patients and methods. A total of 385 patients aged 57 to 79 years with moderate vascular cognitive impairment (MVCI) were examined. The relationship between clinical variants of MVCI and depression with the extent and location of ischemic brain damage, as well as with the state of CVR in various vascular territories, was examined at study entry and 20 months later.

Results. A relationship was found between the neuropsychological profile and severity of VCI and the characteristics of structural brain damage, but more specifically, with a decrease in CVR in the carotid artery (CA) system and a combined decrease in CVR in the CA and vertebrobasilar system (VBS). An association was established between the incidence of depression and the location of ischemic damage in the frontal lobes, a decrease in CVR in the left CA, and a combined decrease in CVR in the CA and VBS.

Conclusion. The state of CVR, determined in various vascular beds, can serve as an early prognostic indicator of developing SCI or depression.

Key words: vascular cognitive impairment; cognitive and emotional disorders; cerebrovascular reactivity.

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