Mexidol in the prevention of intracranial hypertension syndrome with the consequences of closed traumatic brain injury

Authors:
B.M. DORONIN, A.YU. LETYAGIN, O.B. TYSHKEVICH, V.B. DORONIN

Novosibirsk State Medical University, Novosibirsk, 2006

Abstract:
Intracranial hypertension (ICH) syndrome in the late sequelae of closed traumatic brain injury (CTBI) manifests itself as organic and functional disorders of varying severity. This study utilized a method for assessing the severity of ICH by measuring the distances between brainstem structures using magnetic resonance imaging. Calculation of the posterior fossa restriction index allowed us to compare data from 96 patients with ICH, some of whom received Mexidol, with 28 healthy volunteers. The study included a year-long observation period, including a dynamic neurological examination. Comparison of the patient groups with each other and with the parameters of healthy individuals revealed significant differences, manifested in a lesser degree of ICH after treatment with Mexidol. The study demonstrated that long-term treatment with Mexidol is an effective method for preventing episodes of increased intracranial pressure in the late period of mild CTBI and can be recommended for widespread use in both inpatient and outpatient settings.