Personal: Mexidol's effectiveness with carotid endarterctomy in patients with stenosis cerebral atherosclerosis

Authors:

Golovkin V.I. , Popova L.O. , Svetlikov A.V. , Shapovalov A.S.

The purpose of the study is to determine using the cerebral oximetry of the effectiveness of the antihypoxic effect of Mexidol with carotid endarctomy (CE) in patients with stenosis cerebral atherosclerosis.

Material and methods. In 109 patients with stenosis cerebral atherosclerosis with a degree of stenosis of the internal carotid artery 69 ± 7% and a clinical picture of chronic brain ischemia, clinical and psychineological monitoring was carried out in the pre- and postoperative periods of KE. Cerebral cerebral oximetry was perimetically. In 54 patients, the operation was carried out after the course of Mexidol at a dose of 1000 mg/day for 14-15 days. The other 55 people made a comparison group that did not receive Mexidol. Results and conclusion. The difference in the initial
oxygenation of the brain (RSO2) was revealed: 60.8 ± 5.0 and 47.29 ± 5.5%, respectively, in these groups. During the operation in the same groups of patients, the degree of blood saturation with oxygen decreased to 57 and 41%, respectively. On the 7th day after the KE with patients in both groups of both groups, a reliable improvement was obtained when performing the Shulti test to the group that received Mexidol, when evaluating the effectiveness of work and mental stability before and after surgery, which was not observed in patients who did not conduct antioxidant therapy. The use of Mexidol as
antihyplack of KE in patients with stenosis atherosclerosis of extracerebral arteries significantly reduces the degree of brain hypoxia, reduces the time of surgery, improves the neurological status of patients and the implementation of neuropsychological tests in the postoperative period.

Keywords: cerebral stenosis atherosclerosis, carotid endarterctomy, cerebral oximetry, Mexidol.