The effect of Mexidol on physical performance and lactate in the blood of rats in conditions of light desingronosis

Authors

GOSTYUKHINA A.A. , Zaitsev K.V. , Torchoshchina T.A. , Svetlik M.V.

The purpose of the study.

The study of the influence of Mexidol on the dynamics of rats of rats after light or dark deprivation on the swimming dough model with load, as well as an assessment of the state of glycolytic processes in these conditions. Material and methods. The experiment was performed in the spring on 70 rats of the Wistar line. Three groups (30 animals) were in the natural conditions of lighting. One group was not exposed to any influences. Two other groups were presented with physical activity and 30 minutes before it was administered intramuscularly either a physiological solution or Mexidol. Four other groups (40 individuals) 10 days were in the conditions of dark or light deprivation before the presentation of physical activity and received either a physiological solution or Mexidol before the test after the abolition of deprivation. The physical activity model has been chosen a method of forced swimming rats with an additional load daily for 5 days. In the blood serum, the lactate level was determined by the colorimetric method.

Results and conclusion.

Mexol increased the performance of rats in a swimming test in natural lighting conditions and with light desinghronosis, contributed to the formation of cross adaptation to physical exertion under natural lighting conditions and prolonged this condition under the conditions of desinchronosis, did not change the content of lactate in the blood of rats after physical activity in the natural conditions of lighting and dark -skinned deprivation and prevented it light deprivation.

Key words: Mexidol, light and dark deprivation, performance, lactate.