The influence of Mexidol on cerebral mitochondriogenesis at a young age and with aging

Authors:
Yu.I. Kirova1, F.M. Shakova1, E.L. Germanova1, G.A. Romanova1, T.A. Voronin2

1FGBNU "Research Institute of General Pathology and Pathophysiology", Moscow, Russia;
2FGBNU "Research Institute of Pharmacology named after V.V. Zakusova ”, Moscow, Russia

Place of publication: a journal of neurology and psychiatry named after S.S. Korsakova / vol. 120, No. 1, 2020

Resume

The purpose of the study . Studying the ability of the drug Mexidol to induce cerebral mitochondriogenesis in the brain of young and aging rats.
Material and methods. In the cerebral cortex of young (3 months; n = 216) and aging (6, 9, 12 and 15 months; n = 168), outbred rats by Western-Blot Analysis, the level of expression of cerebral mitochondriogenesis protein-markers with course use of Mexidol (20, 40, 100 mg/kg; 20 days; intra-abdominal).
Results. For the first time, it was shown that the exchange rate of Mexidol in doses of 40 and 100 mg/kg is accompanied by a dose-dependent induction of SUCNR1 sucnr1 and mitochondrial biogenesis proteins: PGC-1α transcriptional coactivator, transcription factors (NRF1, TFAM), catalytic subunits of respiratory enzymes (NDUFV2, SDHA, CYT B, COX2) and ATP-syntase (ATP5A) in the cerebral cortex of outbred rats of young and aging age. Mexol-dependent oven-sequences of subunits of mitochondrial enzymes and PGC-1α are noted only with the course use of the drug.
Conclusion. The data obtained indicate the ability of Mexidol to induce cerebral mitochondriogenesis and eliminate mitochondrial dysfunction in young and aging animals and, thus, influence one of the key pathogenetic links in the development of disorders during aging and neurodegenerative diseases.

Keywords: aging, mitochondrial dysfunction, Mexidol, succinate receptor, cerebral mitochondria-
genesis, transcription coactivator PGC-1α

Information about the authors:
Kirova Yu.I. -https://orcid.org/0000-0002-2436-3661; E-mail: Bioenerg@mail.ru
Shakova F.M. -https://orcid.org/0000-0002-0494-2500; E-mail: shakova.fatima@yandex.ru
Germanova E.L. -https://orcid.org/0000-0003-1191-8477; E-mail: Elgerm@mail.ru
Romanova G.A. -https://orcid.org/0000-0003-0090-351x; E-mail: romanovaga@mail.ru
Voronina T.A. -https://orcid.org/0000-0001-7065-469x; voroninata38@gmail.com

How to quote:
Kirova Yu.I., Shakova F.M., Germanova E.L., Romanova G.A., Voronina T.A. The influence of Mexidol on cerebral mitochondrio-
nonse at a young age and in aging. Journal of neurology and psychiatry named after S.S. Korsakova. 2020; 120 (1): 55-62. https://doi.org/10.17116/
jnevro202012001155