Home \ Therapy \ Oxidative stress in the pathogenesis of chronic headache

Oxidizing stress in pathogenesis of chronic headache

Author:
FEDIN A.I.

FGAOU in Russian National Research Medical University named after N.I. Pirogov »Ministry of Health of Russia, Moscow, Russia

Place of publication:
S.S. KORSAKOV JOURNAL OF NEUROLOGY AND PSYCHIATRY, 2024, Vol. 124, No. 10

Abstract:
The article presents new data on the development of oxidative stress (OS) in chronic headache (CH). The main biochemical characteristics of oxidative stress are presented. Changes in MRI spectroscopy and biochemical markers confirming the development of oxidative stress in migraine are described. The absence of significant differences in oxidative stress parameters in migraine with and without aura is emphasized. Pathophysiological differences between migraine and chronic tension-type headache, in which oxidative stress is not detected, are shown. Possible activation of TRPA1 ion channels and calcitonin gene-related peptide in oxidative stress, provoking migraine attacks, is discussed. Directions for drug correction of oxidative stress in chronic headache are considered. Key words: headache, migraine, chronic tension-type headache, oxidative stress, antioxidants.

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Results of an international multicenter, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of sequential therapy with ethylmethylhydroxypyridine succinate in patients in the acute and early recovery periods of ischemic stroke (IS)
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