The dynamics of electroenzelographic and psychophysiological indicators in acute poisoning by neurotoxicants at the rehabilitation stage against the background of various treatment methods

Authors:

Badalyan A.V. , Berezina I.Yu. , Goldfarb Yu.S. , Sumsky L.I.

The purpose of the study . Assessment of the dynamics of the functional activity of the structures of the brain that provide cognitive functions in patients with encephalopathy in acute poisoning with neurotoxic substances at the rehabilitation stage.

Material and methods. 56 patients were examined. The main group was 40 patients, for the treatment of which the intravenous drip administration of Mexidol was used - 10 patients, a combination of Mexidol with non -drug methods of treatment in the form of mesodyeencephalic modulation (MDM) - 10 patients, hyperbaric oxygenation (HBO) - 10 patients and combinations of MDM and HBO - 10 patients. The comparison group was 16 people. All patients were recorded by EEGs caused by auditory (associated event) potentials (SSP) and carried out neuropsychological testing. Results and conclusion. EEG changes noted in all their severity examined with their great severity, and the dominance of signs of violation of the functional activity of the formations of
the diencephalic or mesodyeencephalous level was noted. After the treatment in the main group, positive dynamics was detected in 60% of cases. In 80% of cases, positive dynamics was noted when using a combination of Mexidol, MDM and HBO. Negative dynamics in the main group was noted in 5 (12.5%) cases, while it was more often detected when only Mexidol was used in the treatment process. The results of the primary neuropsychological study showed that in the main group in 97.5% of cases and in 100% of patients of the comparison group, violations of cognitive activity of varying degrees of severity were detected. After the treatment in patients of the main group, 62.5% improved indicators for neuropsychological tests, there was a reduction in the latent period of components N200, P300, an increase in the amplitude of the caused potentials. Thus, the use of patients with encephalopathy in acute poisoning with various neurotoxicants at the stage of rehabilitation of Mexidol, HBO and MDM leads to an improvement in the indicators that reflect the functional state of the brain as a whole and the state of cognitive functions.

Keywords: encephalopathy, acute neurotoxicant poisoning, electroencephalography, auditory -related potential (P300), psychophysiological testing, mexidol, mesodyeencephalmic modulation, hyperbaric oxygenation.