The dynamics of domains of emotional-cognitive and motor disorders in the structure of the PIT syndrome in patients who have undergone acute cerebral failure

Authors:
BELKIN V.A., VASILCHENKO I.E., BELKIN A.A.

Place of publication: Physical and rehabilitation medicine, medical rehabilitation / vol. 6, no. 4, 2024

Autonomous non -profit organization "Clinical Institute of the Brain", Berezovsky, Russia

ABSTRACT
Rationale: The study of options for using pharmacotherapy as an adjuvant component of rehabilitation in patients with acute cerebral insufficiency is of scientific and practical interest.

The aim of the study is to investigate the efficacy and safety of sequential therapy with drugs of the group for the treatment of diseases of the nervous system in a comprehensive rehabilitation program for patients with acute cerebral insufficiency in terms of the impact on the severity of emotional and cognitive disorders, mobility, the severity of the syndrome of consequences of intensive care and the realization of their rehabilitation potential.

Materials and methods. A randomized, interventional, prospective study of 60 patients with acute cerebral insufficiency, divided into two groups, included five visits. Patients in the main group received standard therapy and ethylmethylhydroxypyridine succinate (500 mg/day intravenously for 10 days),
followed by ethylmethylhydroxypyridine succinate FORTE 250 (1 tablet 3 times/day for 8 weeks); patients in the control group received only standard therapy for the same period.
Results. In both groups, there was a comparable improvement in cognitive functions according to the MoCA scale (p
Conclusion. A positive effect of sequential therapy with drugs of the group for the treatment of diseases of the nervous system in a comprehensive rehabilitation program for patients with acute cerebral failure on their emotional-cognitive status, the degree of disability, mobility, the severity of intensive care consequences syndrome and rehabilitation prognosis was demonstrated. A high degree of safety of the studied therapy regimen was proven.
Key words: acute cerebral failure; ethyl methylhydroxypyridine succinate; HADS; MoCA; MRC; Rivermead index; ICS; intensive care consequences syndrome; PITS; rehabilitation potential.
How to cite:
Belkin V.A., Vasilchenko I.E., Belkin A.A. Dynamics of domains of emotional-cognitive and motor disorders in the structure of ITS syndrome
in patients who have suffered acute cerebral failure //