Authors:
A.V. Schulkin
FSBEN in the Ryazan State Medical University of the Russian Federation, Ryazan
Authors:
A.V. Schulkin
FSBEN in the Ryazan State Medical University of the Russian Federation, Ryazan
Place of publication: Farmatek magazine Special Psychiatry / Neurology / 2016
Mexidol is an original domestic drug. The article describes the history of the creation of the drug, outlines modern ideas about its pharmacokinetics (including data on the penetration of Mexidol into mitochondria, as well as its effect on the activity of cytochroma-R450 isform 3A4 and protein-conveyor glycoprotein-r) and pharmacodynamics. From a biochemical point of view, the appropriateness of the use of Mexidol with hypoxia of the brain, the development of oxidative stress, with glutamate exaytotoxicity is substantiated. The comparison of Mexidol and its generics, as well as studies proving the safety of this drug, are presented.
Keywords: Mexidol, ethylmethylhydroxypirinate, pharmacokinetics, pharmacodynamics, safety
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