According to the instructions for medical use, the duration of the course depends on the form and severity of the disease, the prevalence of the process, options for the clinical course and are determined by the attending physician.
To fully utilize the therapeutic potential of Mexidol®, sequential long-term therapy is recommended (EPICA1, 2017): initially 14 days of injections (saturation phase), followed by a transition to Mexidol® or Mexidol® FORTE 250 tabletsfor 2months (therapeutic effect maximization phase). Therapy is administered 2-3 times per year or during periods of exacerbation.
The effectiveness of sequential long-term therapy with Mexidol was confirmed in a recent study by Chukanova E.I. (20192) on the effectiveness and safety of sequential long-term therapy in patients with CCI: significant improvement in cognitive functions (+3.3 points on the MoCA scale), significant regression of asthenic symptoms (-32% on the MFI-20 asthenia scale), significant improvement in motor activity (+49% on the Tinetti scale), significant improvement in the emotional background on the HADS scale (-38% on the anxiety scale and -29% on the depression scale), significant regression of subjective neurological symptoms on the OSNS scale, and the study also noted a high safety profile of this therapy.
Thus, it is necessary to adhere to the principle of consistent long -term therapy to achieve the maximum effect.
According to the instructions for medical use of the drug Mexidol® (solution), one of the recommended methods of administration is intramuscular injection, which, with proper preparation, can be carried out at home3.
1 The results of the randomized, double-blind, multicenter, placebo-controlled, parallel-group study of the efficacy and safety of Mexidol®during long-term sequential therapy in patients with hemispheric ischemic stroke in the acute and early recovery periods (EPICA) were published in the S.S. Korsakov Journal of Neurology and Psychiatry in issue "Stroke" No. 3, 2017; Vol. 2, the leading VAK (Higher Attestation Commission) peer-reviewed publication for neurologists and psychiatrists in Russia. Learn more.
2 "Efficacy and Safety of Mexidol FORTE 250 as Part of Sequential Therapy in Patients with Chronic Cerebral Ischemia," E.I. Chukanova, A.S. Chukanova, S.S. Korsakov Journal of Neurology and Psychiatry, No. 9, 2019. Read more.
website has The neuroreab.ru a very important patient information sheet—a step-by-step guide to administering an intramuscular injection, consisting of four simple steps and illustrated with clear pictures. Intramuscular injections at home are a convenient alternative for patients who are unable to visit a hospital. View the sheet.
